Jonathan N. Flak
Indiana Biosciences Research Institute
39 Papers
331 Citations
Jonathan N. Flak is an academic researcher from Indiana Biosciences Research Institute. The author has contributed to research in topics: Hypothalamus & Internal medicine. The author has an hindex of 23, co-authored 34 publications. Previous affiliations of Jonathan N. Flak include Indiana University & University of Cincinnati Academic Health Center.
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Papers
Role of Prefrontal Cortex Glucocorticoid Receptors in Stress and Emotion
Jessica M. McKlveen,Brent Myers,Jonathan N. Flak,Jana Bundzikova,Matia B. Solomon,Kim B. Seroogy,James P. Herman +6 more
TL;DR: The data indicate a marked functional heterogeneity of glucocorticoid action in the PFC and highlight a prominent role for the infralimbic GR in appropriate stress adaptation, emotional control, and mood regulation.
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Minireview: CNS Mechanisms of Leptin Action.
Jonathan N. Flak,Martin G. Myers +1 more
TL;DR: Low leptin, as with prolonged caloric restriction, promotes a powerful orexigenic signal, decreases energy use via a number of neuroendocrine and autonomic axes, and disrupts glucose homeostasis.
Chronic stress-induced neurotransmitter plasticity in the PVN.
TL;DR: Data are consistent with a role for both glutamate and norepinephrine in chronic stress enhancement of HPA axis excitability, which could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress‐induced hyperreactivity of stress effector systems in the brain.
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance
Jonathan N. Flak,Christa M. Patterson,Alastair S. Garfield,Giuseppe D'Agostino,Paulette B. Goforth,Amy K. Sutton,Paige A. Malec,Jenny Marie T. Wong,Mark Germani,Justin C. Jones,Michael Rajala,Leslie S. Satin,Christopher J. Rhodes,David P. Olson,Robert T. Kennedy,Lora K. Heisler,Martin G. Myers,Martin G. Myers +17 more
TL;DR: A previously unrecognized role for leptin and a population of leptin-regulated neurons that modulate the CRR to meet these challenges are identified in mice and may be a therapeutic target in hypoglycemia.
The brain-to-pancreatic islet neuronal map reveals differential glucose regulation from distinct hypothalamic regions
Wilfredo Rosario,Inderroop Singh,Arnaud Wautlet,Christa M. Patterson,Jonathan N. Flak,Thomas C. Becker,Almas Ali,Natalia A. Tamarina,Louis H. Philipson,Lynn W. Enquist,Martin G. Myers,Christopher J. Rhodes +11 more
TL;DR: Novel direct neuronal effects on pancreatic islets are revealed and distinct regions of the hypothalamus differentially control insulin and glucagon secretion, potentially in partnership to help maintain glucose homeostasis and guard against hypoglycemia.
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