An implantable prosthetic valve having an in situ formable support structure and methods of deploying such a valve are disclosed. In one arrangement, the valve has a base and at least one flow occluder. A first flexible component which is incapable of retaining the valve at a functional site in the arterial vasculature extends proximally of the base of the valve. A second flexible component which is incapable of retaining the valve at a functional site in the arterial vasculature extends distally of the base of the valve. At least one rigidity component combines with at least one of the first and second flexible components to impart sufficient rigidity to the first or second components to retain the valve at the site.

Nonstented heart valves with formed in situ support

A prosthetic valve for implantation within a fluid conducting lumen within a body includes an elongate generally cylindrical radially collapsible valve body scaffold defining a fluid passageway therethrough for retentive positioning within the lumen. A radially collapsible leaf valve member is supported by the scaffold includes a number of valve leafs deflectable between a closed position restricting fluid flow through the passageway and an open position permitting fluid flow through the passageway. The leaf valve member includes an interior leaf valve frame defining a valve leaf aperture which is sealed by a fluid impermeable non-thrombogenic lining to prevent fluid flow therethrough.

Implantable prosthetic valve

Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.

Devices and methods for heart valve repair

Devices and methods for treating heart valves include members that assist the valve in closing during at least a portion of the cardiac cycle. Such devices include members configured to alter the shape of a valve annulus, reposition at least one papillary muscle, and/or plug an orifice of the valve so as to provide a coaptation surface for the valve leaflets.

Devices and methods for heart valve treatment

An anchor deployment tool (30) includes a flexible outer tube (34), within which is positioned a flexible inner shaft (36), and a rotating deployment element (38) coupled to a distal end (39) of the shaft. The tool (30) is configured to provide an anchor storage area (40), which initially stores a plurality of tissue anchors (32), such that the inner shaft (36) passes through channels of the anchors along entire longitudinal lengths of the anchors (32), and the anchors are within the outer tube (34). The rotating deployment element (38) is configured to directly engage the anchors (32) in the anchor storage area (40) one at a time, advance each of the anchors while engaged in a distal direction, and deploy each of the anchors through the distal tube end (42) and into tissue of a subject. Other embodiments are also described.

Multiple anchor delivery tool

A method and apparatus for reducing mitral regurgitation. The apparatus is inserted into the coronary sinus of a patient in the vicinity of the posterior leaflet of the mitral valve, the apparatus being adapted to straighten the natural curvature of at least a portion of the coronary sinus in the vicinity of the posterior leaflet of the mitral valve, whereby to move the posterior annulus anteriorly and thereby improve leaflet coaptation and reduce mitral regurgitation.

Method and apparatus for improving mitral valve function

A prosthesis for treating a body passage includes a micro-porous tubular element and a support element. The tubular element is formed from a thin-walled sheet having a wall thickness of 25 micrometers or less, preferably a coiled-sheet exhibiting temperature-activated shape memory properties. The mesh pattern includes a plurality of openings in the sheet having a maximum dimension of not more than about 200 micrometers, thereby acting as a filter trapping embolic material while facilitating endothelial growth therethrough. The support element includes a plurality of struts, preferably having a thickness of 100-150 micrometers. The support element is preferably an independent component from the tubular element. Alternatively, the support element may be attached to or integrally formed as part of the tubular element. The tubular and support elements are placed on a catheter in contracted conditions and advanced endoluminally to a treatment location within a body passage. The tubular element is deployed, and the support element is expanded to an enlarged condition at the treatment location to engage an interior surface of the tubular element, thereby securing the tubular element and holding the lumen of the treatment location open.

Micro-porous mesh stent with hybrid structure

An apparatus for delivering a stent into a blood vessel includes a sheath having a rounded bullet-shaped distal portion including a plurality of flexible leaflets integrally molded thereto. The stent is disposed in its contracted condition within a lumen of the sheath proximate the distal portion. A bumper is slidably disposed within the lumen that includes a helical compression coil, a bumper element attached to the helical coil including a blunt distal edge for abutting the stent, and an extension element extending distally from the bumper element through the stent and between the leaflets to facilitate introducing the apparatus over a guidewire. The sheath is formed by inserting a bullet into a blunt-ended tube, and inserting the tube into a bullet-shaped bore in a heated die until the tube material is softened and deforms into a rounded bullet shape. Slits are then cut into the distal portion to create the leaflets.

Apparatus for delivering endoluminal prostheses and methods of making and using them

A delivery apparatus (10) includes a tubular sheath (12) including proximal, intermediate (20), and distal (18) portions defining a lumen (16). A wall of the distal (18) portion is transparent, allowing observation of the lumen within the distal portion. The distal portion terminates in a rounded distal tip (14) including a plurality of leaflets (24). A self-expanding stent (50) is disposed within the intermediate portion (20), and a bumper member (30) is slidably disposed within the lumen (16) proximate the stent. Before use, the sheath (12) is retracted to bump the stent (50) forward into the distal portion until the stent (50) is observed within the distal portion (18). After the apparatus has been pre-loaded, the distal portion (18) is advanced into a blood vessel (100), e.g., across a stenosis (102), and the sheath (12) is retracted, causing the leaflets (24) to open and allow the stent (50) to be deployed, whereupon the stent (50) automatically expands to dilate the stenosis (102).

Apparatus for delivering endoluminal prosthesis and methods for preparing such apparatus for delivery

A method for repairing a mitral valve, the method comprising: positioning a crossing guidewire across the mitral valve, the crossing guidewire passing through the annulus of the mitral valve at a first location and passing through the annulus of the mitral valve at a second location; using the crossing guidewire to position a spanning implant across the mitral valve, with the spanning implant extending from the first location to the second location; anchoring the spanning implant at the first location; tensioning the spanning implant so as to draw the first location and the second location together; and anchoring the spanning implant at the second location.

Method and apparatus for repairing a mitral valve

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