Jonathan M. Goodwin
Novartis
7 Papers
1 Citations
Jonathan M. Goodwin is an academic researcher from Novartis. The author has contributed to research in topics: Autophagy & ATG8. The author has an hindex of 2, co-authored 7 publications.
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Papers
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9
Jonathan M. Goodwin,William E. Dowdle,Rowena DeJesus,Zuncai Wang,Philip Bergman,Marek J. Kobylarz,Alicia Lindeman,Ramnik J. Xavier,Gregory McAllister,Beat Nyfeler,Gregory R. Hoffman,Leon Murphy +11 more
TL;DR: Using genome-scale functional screening, this work identifies an alternative lysosomal transport pathway for ferritin that requires FIP200, ATG9A, VPS34, and TAX1BP1 but lacks involvement of the ATG8 lipidation machinery that constitutes classical macroautophagy.
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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Jonathan M. Goodwin,Ward G. Walkup,Kirsty Hooper,Taoyingnan Li,Chieko Kishi-Itakura,Aylwin Ng,Timothy Lehmberg,Archana Jha,Sravya Kommineni,Katherine Fletcher,Jorge Garcia-Fortanet,Yaya Fan,Qing Tang,Menghao Wei,Asmita Agrawal,Sagar R. Budhe,Sreekanth R. Rouduri,Daniel Baird,Jeff Saunders,Janna Kiselar,Mark R. Chance,Andrea Ballabio,Brent A. Appleton,John H. Brumell,Oliver Florey,Leon Murphy +25 more
TL;DR: Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their ac...
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V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy
Kirsty Hooper,Elise Jacquin,Elise Jacquin,Taoyingnan Li,Jonathan M. Goodwin,John H. Brumell,Joanne Durgan,Oliver Florey +7 more
TL;DR: In this article, the authors investigated the role of V-ATPase during non-canonical autophagy and showed that increased V0-V1 engagement is associated with, and sufficient for, CASM activation.
An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.
Marek J. Kobylarz,Jonathan M. Goodwin,Zhao B. Kang,John W. Annand,Sarah Hevi,Ellen O’Mahony,Gregory McAllister,John S. Reece-Hoyes,Qiong Wang,John Alford,Carsten Russ,Alicia Lindeman,Martin Beibel,Guglielmo Roma,Walter Carbone,Judith Knehr,Joseph Loureiro,Christophe Antczak,Dmitri Wiederschain,Leon Murphy,Suchithra Menon,Beat Nyfeler +21 more
TL;DR: Impaired iron mobilization via the VPS34-RAB7A axis drive Vps34-dependence in certain cancer cells, suggesting that iron limitation is the primary driver of V PS34-dependency in RKO cells.
GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis
Jonathan M. Goodwin,Ward G. Walkup,Kirsty Hooper,Taoyingnan Li,Chieko Kishi-Itakura,Aylwin Ng,Timothy Lehmberg,Archana Jha,Sravya Kommineni,Katherine Fletcher,Jorge Garcia-Fortanet,Yaya Fan,Qing Tang,Menghao Wei,Asmita Agrawal,Sagar R. Budhe,Sreekanth R. Rouduri,Daniel Baird,Jeffrey J. Saunders,Janna Kiselar,Mark R. Chance,Andrea Ballabio,Brent A. Appleton,John H. Brumell,Oliver Florey,Leon Murphy +25 more
TL;DR: In this article, the GABARAP-FLCN/FNIP-TFEB axis serves as a universal molecular sensor that coordinates lysosomal homeostasis with perturbations and cargo flux within the autophagy-lysosomal network.
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