Jonathan Lam
University of Southern California
17 Papers
138 Citations
Jonathan Lam is an academic researcher from University of Southern California. The author has contributed to research in topics: Specificity constant & Acquired immune system. The author has an hindex of 12, co-authored 17 publications. Previous affiliations of Jonathan Lam include Imperial College London & National Institutes of Health.
Chat about Author
Papers
Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity
Jerome Kerzerho,Hadi Maazi,Anneliese O. Speak,Natacha Szely,Vincent Lombardi,Bryant Khoo,Stacey Geryak,Jonathan Lam,Pejman Soroosh,Jacques Van Snick,Omid Akbari +10 more
TL;DR: The findings suggest that PD-L2 plays a pivotal role in the regulation of TH9 cell development in chronic AHR, providing novel strategies for modulating adaptive immunity during chronic allergic responses.
ADAMTS13 Substrate Recognition of von Willebrand Factor A2 Domain
Sara Zanardelli,James T. B. Crawley,Chan K N Chan Kwo Chion,Jonathan Lam,Roger J. S. Preston,David A. Lane +5 more
TL;DR: An important role is demonstrated for Asp1614 and surrounding charged residues in the binding and cleavage of the VWFA2 domain by ADAMTS13 and against type 2A von Willebrand disease mutations by site-directed mutagenesis.
87
Double-Stranded RNA Induces Shedding of the 34-kDa Soluble TNFR1 from Human Airway Epithelial Cells via TLR3–TRIF–RIP1-Dependent Signaling: Roles for Dual Oxidase 2- and Caspase-Dependent Pathways
TL;DR: The ability of dsRNA to induce the cleavage and shedding of the 34-kDa sTNFR1 from human bronchial epithelial cells represents a novel mechanism by which innate immune responses to viral infections are modulated.
Role of plasmacytoid dendritic cell subsets in allergic asthma.
TL;DR: Three newly described subsets of pDCs show high potentials for novel therapeutic approaches for the treatment of allergic diseases and are addressed in this review.
33
Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection
Hadi Maazi,Abinav K. Singh,Anneliese O. Speak,Vincent Lombardi,Jonathan Lam,Bryant Khoo,Kyung-Soo Inn,Arlene H. Sharpe,Jae U. Jung,Omid Akbari +9 more
TL;DR: It is demonstrated that lack of PD-L1 expression by iNKT cells reduces the sensitivity to IAV and that the presence ofPD-L2 is important for dampening the deleterious inflammatory responses after IAV infection, which could have clinical implications for developing new therapies for influenza.