Jonathan Klein
Yale University
12 Papers
44 Citations
Jonathan Klein is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Jonathan Klein include University of California, San Francisco.
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Papers
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Anne L. Wyllie,John Fournier,Arnau Casanovas-Massana,Melissa Campbell,Maria Tokuyama,Pavithra Vijayakumar,Joshua L. Warren,Bertie Geng,M. Catherine Muenker,Adam J. Moore,Chantal B.F. Vogels,Mary E. Petrone,Isabel M. Ott,Peiwen Lu,Arvind Venkataraman,Alice Lu-Culligan,Jonathan Klein,Rebecca Earnest,Michael Simonov,Rupak Datta,Ryan Handoko,Nida Naushad,Lorenzo R. Sewanan,Jordan Valdez,Elizabeth B. White,Sarah Lapidus,Chaney C. Kalinich,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Melissa M. Linehan,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takahashi,Manabu Taura,Orr-El Weizman,Patrick Wong,Yexin Yang,Santos Bermejo,Camila D. Odio,Saad B. Omer,Charles S. Dela Cruz,Shelli F. Farhadian,Richard A. Martinello,Akiko Iwasaki,Nathan D. Grubaugh,Albert I. Ko +50 more
TL;DR: Investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV-2 Infection.
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.
Chantal B.F. Vogels,Anderson F. Brito,Anne L. Wyllie,Joseph R. Fauver,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Arnau Casanovas-Massana,M. Catherine Muenker,Adam J. Moore,Jonathan Klein,Peiwen Lu,Alice Lu-Culligan,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takahashi,Manabu Taura,Maria Tokuyama,Arvind Venkataraman,Orr-El Weizman,Patrick Wong,Yexin Yang,Nagarjuna R. Cheemarla,Elizabeth B. White,Sarah Lapidus,Rebecca Earnest,Bertie Geng,Pavithra Vijayakumar,Camila D. Odio,John Fournier,Santos Bermejo,Shelli F. Farhadian,Charles S. Dela Cruz,Akiko Iwasaki,Akiko Iwasaki,Albert I. Ko,Marie L. Landry,Ellen F. Foxman,Nathan D. Grubaugh +45 more
TL;DR: Comparisons of RT–qPCR analytical efficiency and sensitivity show that all primer–probe sets can be used to detect SARS-CoV-2 at 500 viral RNA copies per reaction.
Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR assays
Chantal B.F. Vogels,Anderson F. Brito,Anne L. Wyllie,Joseph R. Fauver,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Arnau Casanovas-Massana,M. Catherine Muenker,Adam J. Moore,Jonathan Klein,Peiwen Lu,Alice Lu-Culligan,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takehashi,Manabu Taura,Maria Tokuyama,Arvind Venkataraman,Orr-El Weizman,Patrick Wong,Yexin Yang,Nagarjuna R. Cheemarla,Elizabeth B. White,Sarah Lapidus,Rebecca Earnest,Bertie Geng,Pavithra Vijayakumar,Camila D. Odio,John Fournier,Santos Bermejo,Shelli F. Farhadian,Charles S. Dela Cruz,Akiko Iwasaki,Albert I. Ko,Marie-Louise Landry,Ellen F. Foxman,Nathan D. Grubaugh +44 more
TL;DR: It is shown that all primer-probe sets can be used to detect SARS-CoV-2 at 500 virus copies per reaction, except for the RdRp-SARSr (Charite) confirmatory primer-Probe set which has low sensitivity.
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2.
Benjamin Israelow,Tianyang Mao,Jonathan Klein,Eric Song,Bridget L. Menasche,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +7 more
TL;DR: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide since 2003 as discussed by the authors.
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Migrant memory B cells secrete luminal antibody in the vagina.
Ji Eun Oh,Norifumi Iijima,Norifumi Iijima,Eric Song,Peiwen Lu,Jonathan Klein,Ruoyi Jiang,Steven H. Kleinstein,Akiko Iwasaki,Akiko Iwasaki +9 more
TL;DR: Results reveal that circulating memory B cells act as a rapidly inducible source of mucosal antibodies in the female reproductive tract, and are shown to be the source of antibody secretion in the vaginal lumen following secondary infection with herpes simplex virus 2.
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