Jonathan Goodwin

TL;DR: In this article, the authors evaluated the potential diagnostic performance of novel 1H magnetic resonance spectroscopic imaging (MRSI) using a semi-localized adiabatic selective refocusing (sLASER) sequence with gradient offset independent adiability (GOIA) pulses in addition to the routine mp-MRI, including T2-weighted imaging, DWI, DWI and quantitative dynamic contrast enhancement (DCE).

TL;DR: In this article, the authors evaluated 4D-CT and a 4DMRI Radial Volumetric Interpolated Breath-Hold Examination (VIBE) sequence with 13 patient respiratory patterns, simulating tumour motion and found no statistically significant difference in mean motion range.

TL;DR: In this article, a robust masking and reconstruction procedure is presented to overcome these limitations and enable automated Quantitative Susceptibility Mapping (QSM) processing for a wide range of use-cases implemented in an open-source software framework.

Abstract: INTRODUCTION The prostatic urethra is an organ at risk for prostate radiotherapy with genitourinary toxicities a common side effect Many external beam radiation therapy protocols call for urethral sparing, and with modulated radiotherapy techniques, the radiation dose distribution can be controlled so that maximum doses do not fall within the prostatic urethral volume Whilst traditional diagnostic MRI sequences provide excellent delineation of the prostate, uncertainty often remains as to the true path of the urethra within the gland This study aims to assess if a high-resolution isotropic 3D T2 MRI series can reduce inter-observer variability in urethral delineation for radiotherapy planning METHODS Five independent observers contoured the prostatic urethra for ten patients on three data sets; a 2 mm axial CT, a diagnostic 3 mm axial T2 TSE MRI and a 09 mm isotropic 3D T2 SPACE MRI The observers were blinded from each other's contours A Dice Similarity Coefficient (DSC) score was calculated using the intersection and union of the five observer contours vs an expert reference contour for each data set RESULTS The mean DSC of the observer vs reference contours was 047 for CT, 062 for T2 TSE and 078 for T2 SPACE (P < 0001) CONCLUSIONS The introduction of a 09 mm isotropic 3D T2 SPACE MRI for treatment planning provides improved urethral visualisation and can lead to a significant reduction in inter-observer variation in prostatic urethral contouring