Jonathan G. Seidman
Harvard University
600 Papers
7.6K Citations
Jonathan G. Seidman is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 137, co-authored 563 publications. Previous affiliations of Jonathan G. Seidman include Albert Einstein College of Medicine & Rutgers University.
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Papers
Burden of Rare Sarcomere Gene Variants in the Framingham and Jackson Heart Study Cohorts
Alexander G. Bick,Jason Flannick,Jason Flannick,Kaoru Ito,Susan Cheng,Ramachandran S. Vasan,Michael Parfenov,Daniel S. Herman,Steven R. DePalma,Namrata Gupta,Stacey Gabriel,Birgit Funke,Heidi L. Rehm,Emelia J. Benjamin,Jayashri Aragam,Herman A. Taylor,Herman A. Taylor,Herman A. Taylor,Ervin R. Fox,Christopher Newton-Cheh,Sekar Kathiresan,Christopher J. O'Donnell,James G. Wilson,David Altshuler,David Altshuler,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman +31 more
TL;DR: Rare sarcomere protein variants cause dominant hypertrophic and dilated cardiomyopathies and were associated with an increased risk for adverse cardiovascular events in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis.
Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
Pradeep Natarajan,Pradeep Natarajan,Nina B. Gold,Nina B. Gold,Alexander G. Bick,Alexander G. Bick,Heather M. McLaughlin,Heather M. McLaughlin,Heather M. McLaughlin,Peter Kraft,Heidi L. Rehm,Heidi L. Rehm,Heidi L. Rehm,Gina M. Peloso,Gina M. Peloso,James G. Wilson,Adolfo Correa,Jonathan G. Seidman,Christine E. Seidman,Sekar Kathiresan,Sekar Kathiresan,Robert C. Green +21 more
TL;DR: Test the hypothesis that persons carrying PVs in any of 56 genes that lead to 24 dominantly inherited, actionable conditions are more likely to exhibit the clinical features of the corresponding diseases than those without PVs, and identify and classify 642 and 4429 unique variants in these 56 genes while blinded to clinical data.
A novel custom resequencing array for dilated cardiomyopathy.
Rebekah S. Zimmerman,Stephanie Cox,Neal K. Lakdawala,Allison L. Cirino,Debora Mancini-Dinardo,Eugene Clark,Annette Leon,Elizabeth Duffy,Emily White,Samantha Baxter,Manal Alaamery,Lisa M. Farwell,Scott T. Weiss,Christine E. Seidman,Jonathan G. Seidman,Carolyn Y. Ho,Heidi L. Rehm,Heidi L. Rehm,Birgit Funke,Birgit Funke,Birgit Funke +20 more
TL;DR: The DCM CardioChip is a highly efficient screening test with a projected clinical sensitivity of 26–29% and compared with traditional Sanger-based sequencing, test cost and turn around time were reduced by ∼50%.
Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat
Michelle D. Johnson,Liqun He,Daniel S. Herman,Hiroko Wakimoto,Caroline A. Wallace,Vaclav Zidek,Petr Mlejnek,Alena Musilova,Miroslava Šimáková,Jaroslav Vorlíček,Vladimir Kren,Ondrej Viklicky,Nathan Qi,Jiaming Wang,Christine E. Seidman,Jonathan G. Seidman,Theodore W. Kurtz,Timothy J. Aitman,Michal Pravenec +18 more
TL;DR: Developing and characterizing a series of congenic strains derived from the spontaneously hypertensive rat (SHR) chromosome 18 and normotensive Brown Norway rat strains provide reagents for identifying causative genes that underlie the chromosome 18 SHR QTLs for hypertension and salt sensitivity.
Cardiac Myosin Binding Protein-C Is Essential for Thick-Filament Stability and Flexural Rigidity
Lori Nyland,Bradley M. Palmer,Zengyi Chen,David W. Maughan,Christine E. Seidman,Jonathan G. Seidman,Laurent Kreplak,Jim O. Vigoreaux +7 more
TL;DR: A new understanding is considered for the critical role of cMyBP-C in defining normal cardiac output by sustaining force and muscle stiffness by calculating a per-filament-specific persistence length, an index of flexural rigidity directly proportional to Young's modulus.