Jonathan G. Seidman

TL;DR: Novel developments in the definition of the genetic causes of HCM have defined both substantial molecular diversity and heterogeneity of the disease expression including (in some relatives) incomplete phenotypic penetrance and delayed, late-onset left ventricular hypertrophy well into adulthood, and strong consideration should be given to extending diagnostic serial echocardiography past adolescence and into mid-life for those family members with a normal eChocardiogram and ECG.

TL;DR: It is shown that the CaSR normally suppresses PTH secretion in the presence of the normal raised (and PTHrP-dependent) fetal calcium level, and that fetal bone resorption is increased.

TL;DR: The ability of ouabain to stimulate pro ANF secretion suggests that an increase in intracellular calcium concentration may promote fusion of secretory granules with atrial cell membranes thereby mediating exocytosis of stored proANF.

TL;DR: In this article , a framework to identify genotype-specific pathomechanisms and therapeutic targets to accelerate the development of precision medicine was proposed using human cardiac electromechanical in-silico modelling and simulation.