Jonathan E. Friedman
Weizmann Institute of Science
15 Papers
235 Citations
Jonathan E. Friedman is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Actin & Electromagnetically induced transparency. The author has an hindex of 8, co-authored 15 publications.
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Papers
Destabilization of actin filaments as a requirement for the secretion of catecholamines from permeabilized chromaffin cells
TL;DR: It is concluded that stimulus‐secretion coupling in chromaffin cells might require the reorganization of actin for modulating both ion transport across the plasma membrane and exocytotic secretion per se.
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Metal ion chelation in neurodegenerative disorders
Itzchak Angel,Adina Bar,Tammy Horovitz,Galia Taler,Michael Krakovsky,Dalia Resnitsky,Gilad Rosenberg,Sarina Striem,Jonathan E. Friedman,Alex Kozak +9 more
TL;DR: This work has shown that disruption in metallochemical reactions and metal‐protein association are associated with chronic neurodegenerative conditions, such as Alzheimer's and Parkinson's disease, as well as with Neurodegeneration triggered by acute cerebral ischaemia, and thus represents excellent targets for exploiting metal ion chelator approaches.
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The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death
TL;DR: Results indicate that DP-b99 is effective in attenuating Zn( 2+) and Ca(2+) surges and protecting neurons against a toxic Zn (2+)-rise and may underlie the efficacy of DP- b99 in stroke treatment.
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A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model.
Eran Dvir,Jonathan E. Friedman,Joo-Yong Lee,Jae-Young Koh,Firas M. Younis,Shaul Raz,Israel Shapiro,Amnon Hoffman,Arik Dahan,Gilad Rosenberg,Itzchak Angel,Alex Kozak,Revital Duvdevani +12 more
TL;DR: DP-155 has significantly lower toxicity in the gut and kidney while maintaining similar efficacy to indomethacin in lowering Aβ42 in the brains of Tg2576 mice, and this superior safety profile highlights DP-155's potential as an improved indometHacin-based therapy for AD.
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The possible implication of membrane-associated actin in stimulus-secretion coupling in adrenal chromaffin cells
TL;DR: It is suggested that plasma membrane-associated microfilaments control the Na+-K+-pump and/or the permeability of Ca2+ ions thus affecting the membrane potential as well as secretion.
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