Jonathan Diedrich
Wayne State University
26 Papers
76 Citations
Jonathan Diedrich is an academic researcher from Wayne State University. The author has contributed to research in topics: Biology & Bone marrow. The author has an hindex of 11, co-authored 13 publications.
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Papers
Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1α activation
Jonathan Diedrich,Erandi Rajagurubandara,Mackenzie K. Herroon,Gargi Mahapatra,Maik Hüttemann,Izabela Podgorski +5 more
TL;DR: Using in vitro and in vivo models of marrow adiposity, it is demonstrated that marrow fat cells promote Warburg phenotype in metastatic prostate cancer cells, and evidence that adipocytes drive metabolic reprogramming of tumor cells via oxygen-independent mechanism of Hif-1α activation that can be reversed by HIF-1 α downregulation is provided.
Identification and discrimination of Pseudomonas aeruginosa bacteria grown in blood and bile by laser-induced breakdown spectroscopy
TL;DR: Pseudomonas aeruginosa bacteria colonies have been analyzed by laser-induced breakdown spectroscopy using nanosecond laser pulses to study the dependence of the LIBS spectrum on growth and environmental conditions.
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Escherichia coli identification and strain discrimination using nanosecond laser-induced breakdown spectroscopy
TL;DR: This analysis showed efficient discrimination between laser-induced breakdown spectroscopy spectra from different strains of a single bacteria species.
Pathogenic Escherichia coli strain discrimination using laser-induced breakdown spectroscopy
TL;DR: In this article, a pathogenic strain of bacteria, Escherichia coli O157:H7 (enterohemorrhagic E. coli or EHEC), has been analyzed by laser-induced breakdown spectroscopy (LIBS) with nanosecond pulses and compared to three nonpathogenic E coli strains: a laboratory strain of K-12 (AB), a derivative of the same strain termed HF4714, and an environmental strain, E coli C (Nino C).
Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression.
TL;DR: This review focuses on the omentum, a visceral white adipose tissue depot, and the bone, a depot for marrow adiposes tissue, as two distinct adipocyte‐rich organs that share common characteristic: they are both sites of significant metastatic growth.