Jonathan Cechetto
Institut Pasteur Korea
36 Papers
760 Citations
Jonathan Cechetto is an academic researcher from Institut Pasteur Korea. The author has contributed to research in topics: Dihydrofolate reductase & Biology. The author has an hindex of 18, co-authored 35 publications. Previous affiliations of Jonathan Cechetto include McMaster University.
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Papers
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
Kevin Pethe,Pablo Bifani,Jichan Jang,Sunhee Kang,Seijin Park,Sujin Ahn,Jan Jiricek,Ju-Young Jung,Hee Kyoung Jeon,Jonathan Cechetto,Thierry Christophe,Honggun Lee,Marie Kempf,Mary Jackson,Anne J. Lenaerts,Hang Ohuong Pham,Victoria Jones,Min Jung Seo,Young-Mi Kim,Mooyoung Seo,Jeong Jea Seo,Dongsik Park,Yoonae Ko,Inhee Choi,Ryangyeo Kim,Se Yeon Kim,Seungbin Lim,Seung-Ae Yim,Jiyoun Nam,Hwankyu Kang,Haejin Kwon,Chun-Taek Oh,Yoojin Cho,Yunhee Jang,Junghwan Kim,Adeline C. Y. Chua,Bee Huat Tan,Mahesh Nanjundappa,Srinivasa P. S. Rao,Whitney Barnes,René Wintjens,John R. Walker,Sylvie Alonso,Saeyeon Lee,Jungjun Kim,Soohyun Oh,Taegwon Oh,Ulf Nehrbass,Sung-Jun Han,Zaesung No,Jinhwa Lee,Priscille Brodin,Sang Nae Cho,Kiyean Nam,Jaeseung Kim +54 more
TL;DR: The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound.
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Patent
Anti viral compounds
Junwon Kim,Jonathan Cechetto,Zaesung No,Thierry Christophe,Tae-Hee Kim,Ji Youn Nam,Wonyoung So,Mina Jo,Taedong Ok,Changmin Park,Min Jung Seo,Jeong-Hun Sohn,Peter Sommer,Annette S Boese,Sung-Jun Han,Youngsam Park,Hwa Pyung Kim +16 more
- 21 Oct 2009
TL;DR: This paper provided small molecule anti-human immunodeficiency virus (anti-HIV) compounds as well as a phenotypic cell-based high throughput screening (HTS) assay for their identification.
254
Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.
Jair L. Siqueira-Neto,Ok-Ryul Song,Hyunrim Oh,Jeong-Hun Sohn,Gyongseon Yang,Jiyoun Nam,Jiyeon Jang,Jonathan Cechetto,Chang Bok Lee,Seunghyun Moon,Auguste Genovesio,Eric Chatelain,Thierry Christophe,Lucio H. Freitas-Junior +13 more
TL;DR: The development and implementation of an automated high-throughput viability screening assay for the discovery of new drugs against Leishmania resulted in two new antileishmanial compounds, bringing promising candidates to the leishmaniasis drug discovery pipeline.
An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages
Jair L. Siqueira-Neto,Seunghyun Moon,Jiyeon Jang,Gyongseon Yang,Changbok Lee,HongKee Moon,Eric Chatelain,Auguste Genovesio,Jonathan Cechetto,Lucio H. Freitas-Junior +9 more
TL;DR: Data corroborate the idea that the intracellular amastigote form of the parasite is the most appropriate to be used in primary screening assay for Leishmania.
145
Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites.
TL;DR: The localization of this protein at specific extramitochondrial sites raises interesting and fundamental questions regarding the possible mechanisms by which these proteins are translocated to such sites.
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