Jonathan C. Howell
Cincinnati Children's Hospital Medical Center
22 Papers
75 Citations
Jonathan C. Howell is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Jonathan C. Howell include University of Cincinnati Academic Health Center.
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Papers
An in vivo model of human small intestine using pluripotent stem cells
Carey L. Watson,Maxime M. Mahe,Jorge O. Múnera,Jonathan C. Howell,Nambirajan Sundaram,Holly M. Poling,Jamie I. Schweitzer,Jefferson E. Vallance,Christopher N. Mayhew,Ying Sun,Gregory A. Grabowski,Stacy R. Finkbeiner,Jason R. Spence,Noah F. Shroyer,James M. Wells,Michael A. Helmrath +15 more
TL;DR: This model of the human small intestine may pave the way for studies of intestinal physiology, disease and translational studies and a role for circulating factors in the intestinal adaptive response is suggested.
Generating human intestinal tissue from pluripotent stem cells in vitro.
TL;DR: A protocol for generating 3D human intestinal tissues (called organoids) in vitro from human pluripotent stem cells (hPSCs) is described, the only method for efficiently directing the differentiation of hPSCs into 3Dhuman intestinal tissue in vitro.
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling.
Jorge O. Múnera,Nambirajan Sundaram,Scott A. Rankin,David E. Hill,Carey L. Watson,Maxime M. Mahe,Jefferson E. Vallance,Noah F. Shroyer,Katie L. Sinagoga,Adrian Zarzoso-Lacoste,Jonathan R. Hudson,Jonathan C. Howell,Praneet Chatuvedi,Jason R. Spence,John M. Shannon,Aaron M. Zorn,Michael A. Helmrath,James M. Wells +17 more
TL;DR: It is found that BMP signaling is required to establish a posterior SATB2+ domain in developing and postnatal intestinal epithelium and BMP-dependent patterning of human hindgut into HCOs is valuable for studying diseases including colitis and colon cancer.
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Late endocrine effects of childhood cancer
Susan R. Rose,Vincent E. Horne,Jonathan C. Howell,Sarah A. Lawson,Meilan M. Rutter,Gylynthia E. Trotman,Sarah D. Corathers +6 more
TL;DR: Optimal endocrine care for survivors of childhood cancer should be delivered in a multidisciplinary setting, providing continuity from acute cancer treatment to long-term follow-up of late endocrine effects throughout the lifespan.
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Vitamin D Deficiency and Survival in Children after Hematopoietic Stem Cell Transplant
Gregory Wallace,Sonata Jodele,Jonathan C. Howell,Kasiani C. Myers,Ashley Teusink,Xueheng Zhao,Kenneth D.R. Setchell,Catherine Holtzapfel,Adam Lane,Cynthia B. Taggart,Benjamin L. Laskin,Stella M. Davies +11 more
TL;DR: It is concluded that all pediatric transplant recipients should be screened for vitamin D deficiency before HSCT and at day 100 post-transplant and that aggressive supplementation is needed to maintain sufficient levels.
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