Jonathan C. Howard
Instituto Gulbenkian de Ciência
182 Papers
4.1K Citations
Jonathan C. Howard is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Major histocompatibility complex & Antigen. The author has an hindex of 55, co-authored 177 publications. Previous affiliations of Jonathan C. Howard include Biotechnology and Biological Sciences Research Council & Agricultural and Food Research Council.
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Papers
Cellular responses to interferon-gamma.
TL;DR: Much of the cellular response to IFN-gamma can be described in terms of a set of integrated molecular programs underlying well-defined physiological systems, for example the induction of efficient antigen processing for MHC-mediated antigen presentation, which play clearly defined roles in pathogen resistance.
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Antibodies to major histocompatibility antigens produced by hybrid cell lines.
TL;DR: FUSION between myeloma cells and spleen cells from immunised donors has been shown to be a successful method of deriving homogeneous anti-SRBC (anti-sheep red blood cell) and anti-TNP antibodies.
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A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
TL;DR: Results indicate that the novel Fe chelators have potent and broad antitumor activity and can overcome resistance to established chemotherapeutics because of their unique mechanism of action.
MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.
Edward V. Deverson,Irene R. Gow,W. John Coadwell,John J. Monaco,Geoffrey W. Butcher,Jonathan C. Howard +5 more
TL;DR: Here it is shown that the rat cim gene6, maps to a highly polymorphic part of the MHC class II region encoding two novel members of the family of transmembrane transporters related to multidrug resistance, known to be capable of transporting proteins and peptides across membranes independently of the classical secretory pathway.
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Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii
Tobias Steinfeldt,Stephanie Könen-Waisman,Lan Tong,Nikolaus Pawlowski,Tobias Lamkemeyer,L. David Sibley,Julia P. Hunn,Jonathan C. Howard +7 more
TL;DR: GTPases of the mouse IRG protein family, mediators of resistance against Toxoplasma gondii in the mouse, are inactivated by a polymorphic kinase of the parasite, resulting in enhanced parasite virulence.