Jonathan A. Cox
University of Liverpool
4 Papers
Jonathan A. Cox is an academic researcher from University of Liverpool. The author has contributed to research in topics: Virus & Enterovirus 71. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Jonathan A. Cox include Agency for Science, Technology and Research.
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Papers
Ability of the Encephalitic Arbovirus Semliki Forest Virus To Cross the Blood-Brain Barrier Is Determined by the Charge of the E2 Glycoprotein.
Mhairi C. Ferguson,Mhairi C. Ferguson,Sirle Saul,Rennos Fragkoudis,Rennos Fragkoudis,Sabine Weisheit,Jonathan A. Cox,Adjanie Patabendige,Karen Sherwood,Mick Watson,Andres Merits,John K. Fazakerley,John K. Fazakerley +12 more
TL;DR: The genetic basis for the difference in phenotype between SFV4 and the virus stocks from which it was derived is elucidated and corrects by engineering a new molecular clone, termed SFV6, which generated a high-titer viremia and was efficiently neuroinvasive and virulent.
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TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection
Siti Naqiah Amrun,Jeslin J. L. Tan,Natasha Y. Rickett,Jonathan A. Cox,Jonathan A. Cox,Bernett Lee,Michael J. Griffiths,Tom Solomon,Tom Solomon,David Perera,Mong How Ooi,Mong How Ooi,Julian A. Hiscox,Julian A. Hiscox,Lisa F. P. Ng +14 more
TL;DR: Mechanistically, this is the first report describing the transcriptome profiles during EV-A71 infections in primary human cells, and the potential involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.
TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
Siti Naqiah Amrun,Jeslin J. L. Tan,Natasha Y. Rickett,Jonathan A. Cox,Jonathan A. Cox,Bernett Lee,Michael J. Griffiths,Tom Solomon,Tom Solomon,David Perera,Mong How Ooi,Mong How Ooi,Julian A. Hiscox,Julian A. Hiscox,Lisa F. P. Ng +14 more
TL;DR: Mechanistically, this is the first report describing the transcriptome profiles during EV71 infections in primary human cells, and the involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.
Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease.
Jonathan A. Cox,Jonathan A. Cox,Julian A. Hiscox,Julian A. Hiscox,Tom Solomon,Tom Solomon,Mong-How Ooi,Mong-How Ooi,Lisa F. P. Ng,Lisa F. P. Ng +9 more
TL;DR: The role of the host–viral interactions of EV71 are discussed together with the various models available to examine: how EV71 utilizes its proteins to cleave host factors and proteins, aiding virus replication; how EV 71 uses its own viral proteins to disrupt host immune responses and aid in its immune evasion.