Jonatan Ersching
Federal University of São Paulo
20 Papers
225 Citations
Jonatan Ersching is an academic researcher from Federal University of São Paulo. The author has contributed to research in topics: Immune system & Germinal center. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of Jonatan Ersching include Universidade Federal de Santa Catarina & Massachusetts Institute of Technology.
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Papers
Germinal Center B Cell Dynamics
TL;DR: Recent developments in the field of GC biology are discussed, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
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Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Jonatan Ersching,Alejo Efeyan,Luka Mesin,Johanne T. Jacobsen,Giulia Pasqual,Brian C. Grabiner,David Dominguez-Sola,David M. Sabatini,Gabriel D. Victora +8 more
TL;DR: In this article, the authors show that positive selection triggered by T-cell help activate the mechanistic target of rapamycin complex 1 (mTORC1), which promotes the anabolic program that supports DZ proliferation.
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Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Jonatan Ersching,Alejo Efeyan,Luka Mesin,Johanne T. Jacobsen,Giulia Pasqual,Brian C. Grabiner,David Dominguez-Sola,Gabriel D. Victora,David M. Sabatini +8 more
- 01 Jun 2017
TL;DR: It is shown that positive selection triggered by T cell help activates the mechanistic target of rapamycin complex 1 (mTORC1), which promotes the anabolic program that supports DZ proliferation and sustains the subsequent dark zone proliferative burst.
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Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses
Oliver Bannard,Oliver Bannard,Simon J. McGowan,Jonatan Ersching,Satoshi Ishido,Gabriel D. Victora,Jeoung-Sook Shin,Jason G. Cyster +7 more
TL;DR: The ubiquitin E3 ligase March1 controls the turnover and surface levels of peptide–MHCII in GC B cells, contributing to optimal GC responses.
Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys.
Jonatan Ersching,Malva Isabel Medina Hernández,Fabrizzio S. Cezarotto,Jovino S. Ferreira,Amely B. Martins,William M. Switzer,Zhiquan Xiang,Hildegund C.J. Ertl,Carlos R. Zanetti,Aguinaldo R. Pinto +9 more
TL;DR: Surprisingly, sera from some New-World monkey species were able to neutralize AdC6 and/or AdC68, the best-studied vector of adenovirus, and the implications for the development of Ad-vector vaccines are discussed in detail.
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