Jonas Pettersson
Umeå University
11 Papers
221 Citations
Jonas Pettersson is an academic researcher from Umeå University. The author has contributed to research in topics: Nerve guidance conduit & Nerve injury. The author has an hindex of 9, co-authored 11 publications.
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Papers
Modulation of Virulence Factor Expression by Pathogen Target Cell Contact
Jonas Pettersson,Roland Nordfelth,Elena Dubinina,Tomas Bergman,Mikael Gustafsson,Karl-Eric Magnusson,Hans Wolf-Watz +6 more
TL;DR: A key role is suggested for the type III secretion system of pathogenic bacteria to coordinate secretion with expression of virulence factors after physical contact with the target cell.
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The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation :
Jonas Pettersson,Anna Holmström,Jim Hill,Sophie Emma Clare Leary,Elisabet Frithz-Lindsten,Anne von Euler-Matell,Eva Carlsson,Richard W. Titball,Åke Forsberg,Hans Wolf-Watz +9 more
TL;DR: It is shown that anti‐LcrV antibodies can block the delivery of Yop effectors into the target cell cytosol, suggesting that LcrV serves an important role in the initiation of the translocation process and provides one possible explanation for the mechanism of LCrV‐induced protective immunity.
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Biodegradable poly-beta-hydroxybutyrate scaffold seeded with Schwann cells to promote spinal cord repair.
TL;DR: It is demonstrated that a biodegradable tubular conduit made from poly-beta-hydroxybutyrate (PHB) scaffold promotes attachment, proliferation and survival of adult Schwann cells and supports marked axonal regeneration within the graft.
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LcrV is a channel size-determining component of the Yop effector translocon of Yersinia
Anna Holmström,Jan Olsson,Peter Cherepanov,Elke Maier,Roland Nordfelth,Jonas Pettersson,Roland Benz,Hans Wolf-Watz,Åke Forsberg +8 more
TL;DR: The size of the channel correlated with the ability to translocate Yop effectors into host cells and it is suggested that LcrV is a size‐determining structural component of the Yop translocon.
147
Fibrin matrix for suspension of regenerative cells in an artificial nerve conduit.
Daniel F. Kalbermatten,Paul J. Kingham,Daljeet Mahay,Cristina Mantovani,Jonas Pettersson,Wassim Raffoul,H. Balcin,Gerhard Pierer,Giorgio Terenghi +8 more
TL;DR: The beneficial combinatory effect of an optimised matrix, cells and conduit material as a step towards bridging nerve gaps which should ultimately lead to improved functional recovery following nerve injury.
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