Jon Cuccui
University of London
44 Papers
48 Citations
Jon Cuccui is an academic researcher from University of London. The author has contributed to research in topics: Glycoconjugate & Campylobacter jejuni. The author has an hindex of 19, co-authored 39 publications. Previous affiliations of Jon Cuccui include Queen Mary University of London.
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Papers
Genome-Wide Saturation Mutagenesis of Burkholderia pseudomallei K96243 Predicts Essential Genes and Novel Targets for Antimicrobial Development
Madeleine G. Moule,Claudia M. Hemsley,Qihui Seet,José Afonso Guerra-Assunção,Jiali Lim,Mitali Sarkar-Tyson,Taane G. Clark,Patrick Tan,Richard W. Titball,Jon Cuccui,Brendan W. Wren +10 more
TL;DR: Transposon-directed insertion site sequencing (TraDIS) of a library of over 106 transposon insertion mutants is described, which provides the level of genome saturation required to identify essential genes in B. pseudomallei and generates a list of genes predicted to be essential, demonstrating that this technique can be used to analyze complex genomes and thus be more widely applied.
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Recent advances in the production of recombinant glycoconjugate vaccines
Emily Kay,Jon Cuccui,Brendan W. Wren +2 more
- 01 May 2019
TL;DR: The component parts of bacterial PGCT are outlined, including recent advances, the advantages and limitations of the technology, and future applications and perspectives.
Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis.
Jon Cuccui,Rebecca M. Thomas,Madeleine G. Moule,Riccardo V. D'Elia,Thomas R. Laws,Dominic C. Mills,Diane Williamson,Timothy P. Atkins,Timothy P. Atkins,Joann L. Prior,Brendan W. Wren +10 more
TL;DR: The application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant glycoconjugate vaccine is described and the conjugation of the Francisella tularensis O-antigen to the Pseudomonas aeruginosa carrier protein exotoxin A is demonstrated.
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Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design.
Vanessa S. Terra,Dominic C. Mills,Laura E. Yates,Sherif Abouelhadid,Jon Cuccui,Brendan W. Wren +5 more
TL;DR: Recent technical developments in this area are highlighted, including the first structural determination of the coupling enzyme PglB, the use of glycotags for optimal glycan attachment and the possible applications of other glycosylation systems and how these may improve and extend PGCT.
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Burkholderia pseudomallei: animal models of infection.
Richard W. Titball,P. Russell,Jon Cuccui,Anna Easton,Ashraful Haque,Tim Atkins,Mitali Sarkar-Tyson,Vicki Harley,Brendan W. Wren,Gregory J. Bancroft +9 more
TL;DR: The findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis.
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