Jon C. Mitchell
Dow AgroSciences
17 Papers
50 Citations
Jon C. Mitchell is an academic researcher from Dow AgroSciences. The author has contributed to research in topics: Xenorhabdus & Gene. The author has an hindex of 6, co-authored 16 publications.
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Papers
Precise genome modification in the crop species Zea mays using zinc-finger nucleases
Vipula K. Shukla,Yannick Doyon,Jeffrey C. Miller,Russell Dekelver,Erica A. Moehle,Sarah E. Worden,Jon C. Mitchell,Nicole L. Arnold,Sunita Gopalan,Xiangdong Meng,Vivian M. Choi,Jeremy M. Rock,Ying-Ying Wu,George E. Katibah,Gao Zhifang,David McCaskill,Matthew A. Simpson,Beth Blakeslee,Scott A. Greenwalt,Holly Jean Butler,Sarah J. Hinkley,Lei Zhang,Edward J. Rebar,Philip D. Gregory,Fyodor D. Urnov +24 more
TL;DR: ZFNs can be used in any plant species amenable to DNA delivery and are established as a new strategy for plant genetic manipulation in basic science and agricultural applications.
1K
A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression.
Gerald B. Watson,Scott Chouinard,Kevin R. Cook,Chaoxian Geng,Chaoxian Geng,Jim M. Gifford,Gustafson Gary D,James M. Hasler,Ignacio Larrinua,Ted Letherer,Jon C. Mitchell,William L. Pak,Vincent L. Salgado,Thomas C. Sparks,Geoff E. Stilwell +14 more
TL;DR: Although a spinosyn-sensitive receptor could not be generated in Xenopus laevis oocytes simply by expressing Dalpha6 alone, co-expression of Dalpha 6 with an additional nAChR subunit, Dalpha5, and the chaperone protein ric-3 resulted in an acetylcholine- and spinosy- sensitive receptor with the pharmacological properties anticipated for a native nA ChR.
141
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.
Donald R. Hahn,Gustafson Gary D,Clive Waldron,Brian Bullard,James D. Jackson,Jon C. Mitchell +5 more
TL;DR: The butenyl-spinosyn genes represent the putative parental gene structure that was naturally engineered by deletion to create the spinosyn genes.
68
Quinoxyfen perturbs signal transduction in barley powdery mildew (Blumeria graminis f.sp. hordei).
Ian E. Wheeler,Derek W. Hollomon,Gustafson Gary D,Jon C. Mitchell,Chris Longhurst,Ziguo Zhang,Sarah J. Gurr +6 more
TL;DR: RT-PCR profiles of signal transduction genes, recorded during wild-type germling morphogenesis, reveals that quinoxyfen alters the accumulation of Protein Kinase C, pkc-like and catalytic subunit of protein Kinase A transcripts, which suggests that resistance bypasses host recognition signals.
34
Patent
Methods of inhibiting insects by treatment with a complex comprising a Photorhabdus insecticidal protein and one or two Xenorhabdus enhancer proteins
Timothy D. Hey,Amanda D. Schleper,Scott Bevan,Scott B. Bintrim,Jon C. Mitchell,Ze Sheng Li,Weiting Ni,Baolong Zhu,Donald J. Merlo,Patricia C. Apel-Birkhold,Meade Thomas +10 more
- 16 Feb 2009
TL;DR: The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from Xenorhabdus, Photorhabdingus, and Paenibacillus, can be used interchangeably with each other.
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