Jon B. Toledo
12 Papers
1 Citations
Jon B. Toledo is an academic researcher. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 4, co-authored 12 publications.
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Papers
Dementia with Lewy bodies: Impact of co‐pathologies and implications for clinical trial design
Jon B. Toledo,Carla Abdelnour,Rimona S. Weil,Daniel Ferreira,Federico Rodriguez-Porcel,Andrea Pilotto,Kathryn A. Wyman-Chick,Michel J. Grothe,Joseph Kane,Angela C. Taylor,Arvid Rongve,Sonja W. Scholz,James B. Leverenz,Bradley F. Boeve,Dag Aarsland,Ian G. McKeith,Simon J.G. Lewis,Iracema Leroi,John B. Taylor +18 more
TL;DR: A framework for integrating multi-modal biomarker fingerprints and step-wise selection and assessment of DLB individuals for clinical trials, monitoring target engagement, and interpreting outcomes in the setting of co-pathologies is proposed.
43
Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum
Jon B. Toledo,Hangfan Liu,Michel J. Grothe,Tanweer Rashid,Lenore J. Launer,Leslie M. Shaw,Haykel Snoussi,Susan R. Heckbert,Michael W. Weiner,John Q. Trojanwoski,Sudha Seshadri,Mohamad Habes +11 more
TL;DR: Each neuroimaging modality captured different aspects of brain aging, genetics, vascular changes, and neurodegeneration leading to individual multimodal phenotyping.
17
Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers
Tanweer Rashid,Jon B. Toledo,Ilya M. Nasrallah,Nicholas M. Pajewski,Sudipto Dolui,John A. Detre,David A. Wolk,Hangfan Liu,Susan R. Heckbert,Robert 'Nick' Bryan,Jeff D. Williamson,Christos Davatzikos,Sudha Seshadri,Lenore J. Launer,Mohamad Habes +14 more
TL;DR: In this article , a post hoc analysis of a randomized clinical trial with 458 participants, intensive blood pressure treatment was associated with reduced progression of white matter lesions, notably in deep white matter tracts, and supported by corresponding changes in fractional anisotropy and mean diffusivity.
A randomized clinical trial of burst vs. spaced physical therapy for Parkinsons disease.
Ka Loong Kelvin Au,Janine Lemos Melo Lobo Jofili Lopes,Alison R Kraus,Kimberly Patton,Lisa Warren,Hanzhi Gao,Joshua K. Wong,Kathryn Moore,Jon B. Toledo,Tamara Stiep,J Frey,Tracy Tholanikunnel,Christopher W. Hess,Leonardo Almeida,Adolfo Ramirez-Zamora,Michael S. Okun +15 more
TL;DR: The optimal timing for physical therapy (PT) delivery in Parkinson's disease (PD) is unknown as mentioned in this paper , and the optimal timing of PT visits over a longer period of time is unknown.
11
Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
Federico Rodriguez-Porcel,Kathryn A. Wyman-Chick,Carla Abdelnour Ruiz,Jon B. Toledo,Daniel Ferreira,Prabitha Urwyler,Rimona S. Weil,Joseph Kane,Andrea Pilotto,Arvid Rongve,B. W. Boeve,John B. Taylor,Ian G. McKeith,Dag Aarsland,Simon J.G. Lewis +14 more
TL;DR: In this article , the authors discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific objective measures.