Joly Sukumaran
Codexis
16 Papers
61 Citations
Joly Sukumaran is an academic researcher from Codexis. The author has contributed to research in topics: Imine & Acyltransferases. The author has an hindex of 5, co-authored 16 publications.
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Papers
Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase
Naga K. Modukuru,Joly Sukumaran,Steven J. Collier,Ann Shu Chan,Anupam Gohel,Gjalt W. Huisman,Raquel Keledjian,Karthik Narayanaswamy,Scott J. Novick,S. M. Palanivel,Derek Smith,Zhang Wei,Brian Wong,Wan Lin Yeo,David Entwistle +14 more
TL;DR: This contribution describes the development of a ketoreductase enzyme over four rounds of directed evolution and the associated process development that enabled a practical, scalable process to (S)-licarbazepine (eslicarbzepine).
38
Patent
Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
Haibin Chen,Steven J. Collier,Jovana Nazor,Joly Sukumaran,Derek Smith,Jeffrey C. Moore,Gregory Hughes,Jacob Janey,Gjalt W. Huisman,Scott J. Novick,Nicholas J. Agard,Oscar Alvizo,Gregory A. Cope,Wan Lin Yeo,Stefanie Ng Minor +14 more
- 09 May 2013
TL;DR: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reduction enzymes, host cells capable of expressing the engineered reductases, and methods of using these engineered PU with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds as mentioned in this paper.
29
Patent
Variant LOVD polypeptides and their uses
Lynne Gilson,Steven J. Collier,Joly Sukumaran,Wan Lin Yeo,Oscar Alviso,Ee Ling Teo,Robert John Wilson,Junye Xu +7 more
- 24 Sep 2010
TL;DR: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound as mentioned in this paper, which can be used to synthesize statin compounds for statin drugs.
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Synthesis of (−)-deoxynupharidine by allenic hydroxylamine cyclisation
TL;DR: (−)-Deoxynupharidine has been synthesised via an intermediate that can also be used for other Nuphar alkaloids and significant steps include the optimised enzymatic resolution of an allenic alcohol and stereoelectronically controlled enolate alkylation.
8
Patent
Improved lov-d acyltransferase mediated acylation
Steven J. Collier,Ee Ling Teo,Joly Sukumaran,Robert John Wilson,Junye Xu +4 more
- 24 Sep 2010
TL;DR: In this paper, the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and thiol scavengers and/or precipitating agents is presented.
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