Jolanta M. Dzik
Nencki Institute of Experimental Biology
38 Papers
304 Citations
Jolanta M. Dzik is an academic researcher from Nencki Institute of Experimental Biology. The author has contributed to research in topics: Thymidylate synthase & Alveolar macrophage. The author has an hindex of 11, co-authored 35 publications. Previous affiliations of Jolanta M. Dzik include Polish Academy of Sciences & New York State Department of Health.
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Papers
The ancestry and cumulative evolution of immune reactions.
TL;DR: The adaptive immune system of mammals is also deeply rooted in the metazoan evolution, and its functional convergence was presumably enabled by the general similarity of the lectin-like recognition domain three-dimensional structure.
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Maria Bretner,Tadeusz Kulikowski,Jolanta M. Dzik,Małgorzata Balińska,Wojciech Rode,David Shugar +5 more
TL;DR: The beta-anomer 1 exhibited antitumor activity in a mouse leukemic cell line L5178Y (IC50 approximately 10(-6) M), hence 40-100-fold weaker than 5-fluoro-dUrd, but exhibited at least 10-fold higher selectivity with respect to the tumor cells than the beta-Anomer 1.
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Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Rogerio R. Sotelo-Mundo,Joanna Ciesla,Jolanta M. Dzik,Wojciech Rode,Frank Maley,Gladys F. Maley,Larry W. Hardy,W.R. Montfort +7 more
TL;DR: Two crystal structures of rat thymidylate synthase (TS) complexed with dUMP and the anticancer drug Tomudex have been determined and suggest that the rat protein undergoes a ligand-induced conformational change similar to that of the Escherichia coli protein.
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Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
Wojciech Rode,Zbigniew Zieliński,Jolanta M. Dzik,Tadeusz Kulikowski,Maria Bretner,Borys Kierdaszuk,Joanna Cieśla,David Shugar +7 more
TL;DR: Kinetic studies with purified enzyme from five sources demonstrated that addition of a 5-fluoro substituent to N4-OH-dCMP increased its affinity from 2- to 20-fold for the enzyme from different sources.
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A non-classical type of alveolar macrophage response to Trichinella spiralis infection.
TL;DR: BCG treatment invoked an alternative type of activation mechanism, reflected by stimulation of macrophage arginase, but not iNOS, activity, which affected the enzyme distribution between intracellular and extracellular fractions, and properties, rather than total activity.
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