A congenital persistent swine fever infection. I. Clinical and virological observations

CHAPTER 3 – The Nervous System

In this chapter the gross pathology and the light and electron microscopical changes occurring in the acute and chronic form of Classical Swine Fever (CSF) will be described and their pathogenesis discussed. It will then be shown that in recent years considerable progress has been made in the understanding of the pathogenesis of consumptive coagulopathy and disseminated intravascular coagulation. A special problem presents the transplacental infection of the developing foetus. These infections may result in prenatal death, the development of a number of foetal abnormalities, stillbirth and, most important, congenital persistent HC virus infection. The chapter concludes with a discussion of the viral pathogenesis of this disease.

Pathology and Pathogenesis of the Disease

Congenital infections with nonarbo togaviruses.

Nonpurulent encephalomyelitis and polymyositis were primary lesions of cattle and goats experimentally infected with Akabane virus. Two caprine fetuses, two months old, were infected placentally and examined 11 days after inoculation; twin caprine fetuses, three months old, were inoculated intramuscularly through the dam's uterus and examined nine days after inoculation. Both lesions were seen in each fetus. Reactive proliferation of immature endothelial cells was a significant encephalitic change. Myositic changes included parenchymal degeneration and cell infiltration in fetuses in the myotubule phase and the beginning of the myofiber phase. Only nonpurulent encephalomyelitis was seen in six calves 14 days to one year old, inoculated intracerebrally and examined six to 47 days after inoculation. Nerve-cell degeneration, neurological mobilization, and perivascular cuffs were typical encephalitic changes in the calves. Five fetuses were infected transplacentally and had polymyositis alone. The four bovine fetuses, two to six months old, were examined nine to 18 days after inoculation, and one caprine fetus, one month old, was examined 11 days after inoculation. Neither encephalomyelitis nor polymyositis was seen in four calves under one year old that were inoculated intravenously.

https://journals.sagepub.com/doi/pdf/10.1177/030098588201900305

Akabane Disease in Cattle: Congenital Abnormalities caused by Viral Infection. Experimental Disease:

Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Johnson Kp

Author Tools

Chat about Author

Papers

Multiple fetal malformations due to persistent viral infection. I. Abortion, intrauterine death, and gross abnormalities in fetal swine infected with hog cholera vaccine virus.