John W. Wong
Pfizer
31 Papers
217 Citations
John W. Wong is an academic researcher from Pfizer. The author has contributed to research in topics: Chemistry & Enantioselective synthesis. The author has an hindex of 14, co-authored 31 publications.
Chat about Author
Papers
The Evolution of an Amine Dehydrogenase Biocatalyst for the Asymmetric Production of Chiral Amines
TL;DR: The broad specificity, high selectivity, and near complete conversion render this amine dehydrogenase an attractive target for further evolution toward pharmaceutical compounds and subsequent application.
145
Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin
Katarina S. Midelfort,Rajesh Kumar,Seungil Han,Michael J. Karmilowicz,Kevin McConnell,Daniel K. Gehlhaar,Anil Mistry,Jeanne S. Chang,Marie Anderson,Alan Villalobos,Jeremy Minshull,Sridhar Govindarajan,John W. Wong +12 more
TL;DR: crystal structures of Vfat wild type and an improved variant (Vfat variant r414) were solved and they are reported here for the first time and provides insight into the critical residues for substrate specificity for the transamination of (R)-ethyl 5-methyl 3-oxooctanoate and structurally related β-ketoesters.
133
Chemoenzymatic asymmetric synthesis of pregabalin precursors via asymmetric bioreduction of β-cyanoacrylate esters using ene-reductases.
Christoph K. Winkler,Dorina Clay,Simon J. C. Davies,Pat O'Neill,Paul McDaid,Sebastien Debarge,Jeremy Steflik,Mike Karmilowicz,John W. Wong,Kurt Faber +9 more
TL;DR: The asymmetric bioreduction of a library of β-cyanoacrylate esters using ene-reductases was studied with the aim to provide a biocatalytic route to precursors for GABA analogues, such as pregabalin.
88
Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum.
Toshiyuki Saito,Fukumatsu Aoki,Hideo Hirai,Taisuke Inagaki,Yasue Matsunaga,Tatsuo Sakakibara,Shinichi Sakemi,Yumiko Suzuki,Shuzo Watanabe,Osamu Suga,Tetsujo Sujaku,Adam A. Smogowicz,Truesdell Susan Jane,John W. Wong,Atsushi Nagahisa,Yasuhiro Kojima,Nakao Kojima +16 more
TL;DR: The suppression of electrically-stimulated twitch responses of rabbit vas deferens was recovered by adding a selective kappa opioid receptor antagonist nor-binaltorphimine, indicating that 1 is a kappa opioids receptor agonist.
73