John W. Mellors
University of Pittsburgh
443 Papers
5.5K Citations
John W. Mellors is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 78, co-authored 373 publications. Previous affiliations of John W. Mellors include East China University of Science and Technology & Case Western Reserve University.
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Papers
Achieving Viral Suppression in 90% of People Living With Human Immunodeficiency Virus on Antiretroviral Therapy in Low- and Middle-Income Countries: Progress, Challenges, and Opportunities.
Jean B. Nachega,Nadia A. Sam-Agudu,Nadia A. Sam-Agudu,Lynne M. Mofenson,Mauro Schechter,John W. Mellors +5 more
TL;DR: There is no simple and/or single approach to achieve the last 90%.
Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research
Dongzhu Ma,Cuiling Xu,Anthony R. Cillo,Benjamin B. Policicchio,Jan Kristoff,George S. Haret-Richter,John W. Mellors,Ivona Pandrea,Cristian Apetrei +8 more
TL;DR: In SIVsab-infected RMs, viral replication is controlled to <0 to 3 copies/ml, about one-third of the virus strains in reservoirs are replication incompetent, and rebounding virus after CD8+ cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding.
Cost-effectiveness of easy-access, risk-informed oral pre-exposure prophylaxis in HIV epidemics in sub-Saharan Africa: a modelling study
Andrew N. Phillips,Anna Bershteyn,Paul Revill,Loveleen Bansi-Matharu,Katharine Kripke,Marie-Claude Boily,Rowan Martin-Hughes,Leigh F. Johnson,Zindoga Mukandavire,Lise Jamieson,Gesine Meyer-Rath,Timothy B. Hallett,Debra ten Brink,Sherrie L Kelly,Brooke E Nichols,Eran Bendavid,Edinah Mudimu,Isaac Taramusi,Jennifer A. Smith,Shona Dalal,Rachel Baggaley,Siobhan Crowley,Fern Terris-Prestholt,Peter Godfrey-Faussett,Irene Mukui,Andreas Hahn,Kelsey K. Case,Diane V. Havlir,Maya L. Petersen,Moses R. Kamya,Catherine A. Koss,Laura B. Balzer,Tsitsi Apollo,Thato Chidarikire,John W. Mellors,Urvi M. Parikh,Catherine Godfrey,Valentina Cambiano +37 more
TL;DR: Making PrEP easily accessible for all adults in sub-Saharan Africa in the context of community education leads to risk-informed use, PrEP is likely to be cost-effective in settings with prevalence of HIV viral load greater than 1000 copies per mL among all adults higher than 2%, suggesting the need for implementation of such approaches.
Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
Chun Chen,James W. Saville,Michelle Marti,Alexandra Schäfer,Mary Hongying Cheng,Dhiraj Mannar,Xing Zhu,Alison M. Berezuk,Anupam Banerjee,Michele D. Sobolewski,A. Kim,Benjamin R. Treat,Priscila Mayrelle da Silva Castanha,Nathan Enick,Kevin McCormick,Xianglei Liu,Cynthia Adams,M. G. Hines,Zehua Sun,Weizao Chen,Jana L. Jacobs,Simon M. Barratt-Boyes,John W. Mellors,Ralph S. Baric,Ivet Bahar,Dimiter S. Dimitrov,Sriram Subramaniam,David R. Martinez,Wei Liu +28 more
TL;DR: In this paper , a human VH domain, F6, was characterized by sequentially panning large phage-displayed VH libraries against receptor binding domains (RBDs) containing VOC mutations.
Deep Sequencing Analysis of Individual HIV-1 Proviruses Reveals Frequent Asymmetric Long Terminal Repeats
Kevin Joseph,Elias K. Halvas,Leah Brandt,Sean C. Patro,Jason W. Rausch,Abha Chopra,Simon Mallal,Mary F. Kearney,John M. Cioffi,John W. Mellors +9 more
TL;DR: A novel, integrated, two-step method (individual proviral sequencing assay [IPSA]) that amplifies the host-virus junction and the full-length provirus except for the last 69 bp of the 3′ long terminal repeat (LTR).