John W. Mellors
University of Pittsburgh
443 Papers
5.5K Citations
John W. Mellors is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 78, co-authored 373 publications. Previous affiliations of John W. Mellors include East China University of Science and Technology & Case Western Reserve University.
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Papers
Associations of HIV persistence, cigarette smoking, inflammation, and pulmonary dysfunction in people with HIV on antiretroviral therapy
Joshua C. Cyktor,Shulin Qin,Brittany Staines,Mehdi Nouraie,Meghan Fitzpatrick,Cathy Kessinger,Rebecca S. DeSensi,Laurence Huang,Charles R. Rinaldo,Lawrence A. Kingsley,Phyllis C. Tien,John W. Mellors,Alison Morris +12 more
TL;DR: Investigation of the relationship between measures of HIV persistence with antiretroviral therapy and cigarette smoking, systemic markers of inflammation, and pulmonary function found HIV DNA, CA-RNA, and plasma HIV RNA were not significantly associated with any measure of pulmonary function or inflammation.
No Evidence that Ongoing HIV-Specific Immune Responses Contribute to Persistent Inflammation and Immune Activation in Persons on Long-Term ART
Adam R. Ward,Adam R. Ward,Allison S. Thomas,Eva M. Stevenson,Szu-Han Huang,Szu-Han Huang,Sheila M. Keating,Sheila M. Keating,Rajesh T. Gandhi,Deborah McMahon,Ronald J. Bosch,Bernard J.C. Macatangay,Joshua C. Cyktor,Joseph J. Eron,John W. Mellors,R. Brad Jones,R. Brad Jones +16 more
TL;DR: In this article, the potential role of the HIV-specific adaptive immune response, which also persists under ART, in driving levels of clinically relevant biomarkers was investigated, but the relationship between HIV persistence parameters and inflammatory biomarkers were not influenced by either HIVspecific T-cell responses or antibody levels.
HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy
Eva M. Stevenson,Adam R. Ward,Adam R. Ward,Ronald Truong,Allison S. Thomas,Szu-Han Huang,Szu-Han Huang,Thomas R. Dilling,Sandra Terry,John K. Bui,Talia M. Mota,Ali Danesh,Guinevere Q. Lee,Andrea Gramatica,Pragya Khadka,Winiffer D. Conce Alberto,Rajesh T. Gandhi,Deborah McMahon,Christina M. Lalama,Ronald J. Bosch,Bernard J.C. Macatangay,Joshua C. Cyktor,Joseph J. Eron,John W. Mellors,R. Brad Jones,R. Brad Jones +25 more
TL;DR: It is shown that T-cell responses to autologous reservoir viruses persist over years, and that the maintenance of HIV-Nef-specific responses was uniquely associated with residual frequencies of infected cells.
Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Jana L. Jacobs,Ghady Haidar,Asma Naqvi,Kevin McCormick,Michele D. Sobolewski,Benjamin R. Treat,Amy Heaps,Kailey Hughes Kramer,E. McCreary,J. Ryan Bariola,Cynthia Klamar-Blain,Bernard J.C. Macatangay,Dimiter S. Dimitrov,Wei Liu,Anastasios Raptis,Rahil Sethi,Uma Chandran,Simon M. Barratt-Boyes,Urvi M. Parikh,John W. Mellors +19 more
TL;DR: In this paper , an immunocompromised patient treated with monoclonal antibodies experienced a rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene.