John W. Mellors
University of Pittsburgh
443 Papers
5.5K Citations
John W. Mellors is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Viral load. The author has an hindex of 78, co-authored 373 publications. Previous affiliations of John W. Mellors include East China University of Science and Technology & Case Western Reserve University.
Chat about Author
Papers
Virologic, immunologic, and immune activation markers as predictors of HIV-associated weight loss prior to AIDS
Robert H. Lyles,Alice M. Tang,Ellen Smit,John W. Mellors,Joseph B. Margolick,Barbara R. Visscher,John P. Phair,Neil M. H. Graham +7 more
TL;DR: Although baseline virologic, immunologic, and immune activation markers all predicted weight loss events in AIDS-free HIV-positive men, HIV RNA displayed the best discrimination.
16
A randomized, placebo-controlled trial of abacavir intensification in HIV-1-infected adults with virologic suppression on a protease inhibitor-containing regimen.
Scott M. Hammer,Heather J. Ribaudo,Roland L. Bassett,John W. Mellors,Lisa M. Demeter,Robert W. Coombs,Judith S. Currier,Gene D. Morse,John G. Gerber,Ana Martinez,William Spreen,Margaret A. Fischl,Kathleen Squires +12 more
TL;DR: The strategy of intensification with abacavir in patients who are virologically suppressed on a stable antiretroviral regimen does not confer a clinical or virologic benefit.
Brief Report: No Evidence for an Association Between Statin Use and Lower Biomarkers of HIV Persistence or Immune Activation/Inflammation During Effective ART.
Roger Bedimo,Hanna Mar,Ronald J. Bosch,Henning Drechsler,Joshua C. Cyktor,Barnard J. C. Macatangay,Christina M. Lalama,Charles R. Rinaldo,Ann C. Collier,Catherine Godfrey,Evelyn Hogg,Christopher Hensel,Joseph J. Eron,Deborah McMahon,John W. Mellors,Pablo Tebas,Rajesh T. Gandhi,A Study Team +17 more
TL;DR: The results do not support a major role for statins in reducing HIV persistence although an early transient effect cannot be excluded and Prospective, randomized studies are needed to confirm these findings.
15
•Journal Article
Stability of the latent reservoir for HIV-1 in patients receiving valproic acid. Commentary
Robert T. Schooley,John W. Mellors,Janet D. Siliciano,Jun Lai,Marc Callender,Eleanor Pitt,Hao Zhang,Joseph B. Margolick,Joel E. Gallant,Joseph Cofrancesco,Richard D. Moore,Stephen J. Gange,Robert F. Silicianol +12 more
TL;DR: It is concluded that the clinical use of VA has no ancillary effect on the decay of the latent reservoir for HIV-1 and the eventual eradication of the infection.
15
HIV-1 Drug Resistance Resulting from Antiretroviral Therapy Far Exceeds That From Pre-exposure Prophylaxis
Urvi M. Parikh,John W. Mellors +1 more
TL;DR: An increase in transmitted drug resistance in resource-limited settings is reported, from previous estimates of <5% using World Health Organization threshold surveys conducted before 2008 to as high as 12.3% in various regions in sub–Saharan Africa, particularly in areas of treatment scale-up.
15