John W. Dankwardt
Sunovion
5 Papers
John W. Dankwardt is an academic researcher from Sunovion. The author has contributed to research in topics: Chemistry & Indole test. The author has an hindex of 4, co-authored 5 publications.
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Papers
A ligand-free, copper-catalyzed cascade sequence to indole-2-carboxylic esters
TL;DR: A variety of indole-2-carboxylic esters are accessible in yields up to 61% through a ligand-free, copper-catalyzed reaction of a series of commercially available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent ethyl acetamidoacetate.
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Directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles with NaHMDS
TL;DR: In this article, a mild and regioselective functionalization protocol for 3-bromofuran and analogs has been developed for selective metalation and functionalization.
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A Ligand‐Free, Copper‐Catalyzed Cascade Sequence to Indole‐2‐carboxylic Esters.
TL;DR: In this paper, it is demonstrated that the reaction of o-halobenzaldehydes and amidoacetates offers a ready access to the title compounds without the need of an external ligand.
Practical Nonazide Synthesis of a d-Amino Acid Oxidase Inhibitor via a Sequential Erlenmeyer–Plöchl Reaction and Ligand-Free Copper(I) Amination Protocol
TL;DR: In this article, a synthetic route to fused heterocycle 5 (R1 = Et) was developed that avoids the use of troublesome azido functionality by using highly regioselective formylation conditions.
Copper-Catalyzed Synthesis of Indoles and Related Heterocycles in Renewable Solvents
TL;DR: An efficient one-pot cascade to indoles and related fused heterocycles has been demonstrated in renewable solvents, thereby eliminating the previously required dipolar aprotic solvent.