John Valdes
University of Michigan
12 Papers
263 Citations
John Valdes is an academic researcher from University of Michigan. The author has contributed to research in topics: Huntington's disease & Locus (genetics). The author has an hindex of 10, co-authored 12 publications. Previous affiliations of John Valdes include University of Iowa.
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Papers
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
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Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues.
Theresa V. Strong,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Karina Boehm,Manju Swaroop,Kevin W. Kaatz,Francis S. Collins,Roger L. Albin +8 more
TL;DR: The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.
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Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder
TL;DR: An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results, but if the provisional association can be replicated, the findings are consistent with CCK(-36C-->T) being a disease-susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically.
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A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene.
Sarah Baxendale,Marcy E. MacDonald,Richard Mott,Fiona Francis,Carol Lin,Susan F. Kirby,Marianne James,Günther Zehetner,Holger Hummerich,John Valdes,Francis S. Collins,Larry J. Deaven,James F. Gusella,Hans Lehrach,Gillian P. Bates +14 more
TL;DR: The construction of a cosmid and P1 clone contig spanning the region containing the HD gene, and the establishment of a detailed, high resolution restriction map are described.
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Characterization of a yeast artificial chromosome contig spanning the Huntington's disease gene candidate region.
Gillian P. Bates,John Valdes,Holger Hummerich,Sarah Baxendale,D. Le Paslier,Anthony P. Monaco,Danilo A. Tagle,Marcy E. MacDonald,Michael R. Altherr,Mark T. Ross,Bernard H. Brownstein,David R. Bentley,John J. Wasmuth,James F. Gusella,Daniel Cohen,Frank H. Collins,Hans Lehrach +16 more
TL;DR: The establishment of a YAC contig which spans the region most likely to contain the HD mutation is an essential step in the isolation of the HD gene.
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