John T. Leith
Brown University
87 Papers
1.3K Citations
John T. Leith is an academic researcher from Brown University. The author has contributed to research in topics: Cell killing & Clone (cell biology). The author has an hindex of 28, co-authored 87 publications. Previous affiliations of John T. Leith include Lawrence Berkeley National Laboratory & University of California, San Francisco.
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Papers
•Journal Article
Growth Interaction in Vivo between Tumor Subpopulations Derived from a Single Mouse Mammary Tumor
TL;DR: In BALB/cfC3H mice, the presence of line 410 tumors on one flank inhibited both 410 and 168 tumors on the other flank, suggesting immunity to tumor-associated antigens may be one way by which cells of a heterogeneous tumor can interact.
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•Journal Article
Differential responses to x-irradiation of subpopulations of two heterogeneous human carcinomas in vitro
John T. Leith,Daniel L. Dexter,DeWyngaert Jk,Zeman Em,Ming Yu W. Chu,Paul Calabresi,Arvin S. Glicksman +6 more
TL;DR: In this article, the responses of two heterogeneous human cancer cell lines and their derivative clones to graded single doses of X-rays were examined in vitro, and the results indicated that failure of some human carcinomas to respond to physical treatment modalities can be due to preexisting resistant subpopulations.
112
Cancer Cell Gene Expression Modulated from Plasma Membrane Integrin αvβ3 by Thyroid Hormone and Nanoparticulate Tetrac
Paul J. Davis,Gennadi V. Glinsky,Hung Yun Lin,John T. Leith,Aleck Hercbergs,Heng Yuan Tang,Osnat Ashur-Fabian,Sandra Incerpi,Shaker A. Mousa +8 more
TL;DR: Previously unrecognized cell surface-initiated actions of thyroid hormone and tetrac formulations at αvβ3 offer opportunities to regulate angiogenesis and multiple aspects of cancer cell behavior.
Radiobiological studies of PC-3 and DU-145 human prostate cancer cells: x-ray sensitivity in vitro and hypoxic fractions of xenografted tumors in vivo.
TL;DR: The data from the in vitro experiments show that the DU-145 cell line is significantly more radioresistant than the PC-3 cell line, and significantly variability exists within human prostate tumors in regard to both intrinsic radiosensitivity in vitro and levels of hypoxia in vivo.
57
•Journal Article
Alteration of the Survival Response of Two Human Colon Carcinoma Subpopulations to X-Irradiation by N,N-Dimethylformamide
TL;DR: Growth of colon cancer cells in DMF medium prior to irradiation, which results in cell differentiation, actually increases the sensitivity of cells to X-rays.
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