John Stephen
University of Birmingham
67 Papers
1.1K Citations
John Stephen is an academic researcher from University of Birmingham. The author has contributed to research in topics: Clostridium difficile & Clostridium difficile toxin A. The author has an hindex of 25, co-authored 66 publications.
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Papers
Clostridium difficile--a spectrum of virulence and analysis of putative virulence determinants in the hamster model of antibiotic-associated colitis.
S. P. Borriello,Julian M. Ketley,Timothy J. Mitchell,Fiona E. Barclay,A. R. Welch,A. B. Price,John Stephen +6 more
TL;DR: The data support the view that high virulence of C. difficile is determined by efficient disease-inducing colonisation of the gut and the ability to generate, rapidly, high levels of toxin A in vivo.
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Growth of Clostridium difficile and production of toxins A and B in complex and defined media.
TL;DR: Toxin A production was not inextricably linked to production of toxin B since conditions were found in which only one or other toxin was produced.
A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs.
Andrew Winter,Spyridon Comis,Michael P. Osborne,M J Tarlow,John Stephen,P W Andrew,Jonathan Hill,Timothy J. Mitchell +7 more
TL;DR: Pneumolysin seems to be the principal cause of cochlear damage in this model of meningogenic deafness, and no clear pathogenic role was demonstrated for neuraminidase.
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An electron microscopic investigation of time-related changes in the intestine of neonatal mice infected with murine rotavirus.
Michael P. Osborne,S. J. Haddon,A. J. Spencer,J. Collins,W. G. Starkey,T. S. Wallis,G. J. Clarke,Kim J. Worton,D. C. A. Candy,John Stephen +9 more
TL;DR: It is suggested that many of the pathological features following rotav virus infection result from rotavirus-induced ischemia of villi and that diarrhea results from malabsorption of fluid by damaged villo and hypersecretion of ions released from increased numbers of dividing cells at villus-crypt borders.
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Interaction of Salmonella choleraesuis, Salmonella dublin and Salmonella typhimurium with porcine and bovine terminal ileum in vivo.
TL;DR: Three hours after loop inoculation, each serotype was recovered in comparable numbers from either absorptive or Peyer's patch mucosae present in the same ileal loop, indicating that both types of tissue are involved in the early stages of the enteropathogenic process induced by both serotypes.