John S. Cottrell
The Hertz Corporation
37 Papers
368 Citations
John S. Cottrell is an academic researcher from The Hertz Corporation. The author has contributed to research in topics: Mass spectrometry & Matrix (chemical analysis). The author has an hindex of 18, co-authored 37 publications. Previous affiliations of John S. Cottrell include National Institutes of Health.
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Papers
Probability-based protein identification by searching sequence databases using mass spectrometry data.
TL;DR: A new computer program, Mascot, is presented, which integrates all three types of search for protein identification by searching a sequence database using mass spectrometry data, and the scoring algorithm is probability based.
8.8K
Unimod: Protein modifications for mass spectrometry.
David M. Creasy,John S. Cottrell +1 more
TL;DR: Unimod is a database of protein modifications for use in mass spectrometry applications, especially protein identification and de novo sequencing, which contains accurate and verifiable values, derived from elemental compositions, for the mass differences introduced by both natural and artificial modifications.
385
Error tolerant searching of uninterpreted tandem mass spectrometry data.
David M. Creasy,John S. Cottrell +1 more
TL;DR: An error tolerant mode for database matching of uninterpreted tandem mass spectrometry data is described, and can only reveal new matches to proteins that already have at least one significant peptide match.
241
Sample immobilization protocols for matrix-asssisted laser-desorption mass spectrometry
TL;DR: Methods are described for the purification of proteins prior to analysis by matrix-assisted laser-desorption mass spectrometry, finding that a layer of electrosprayed nitrocellulose gave better results than the roughened gold surface of an untreated target.
143
The analysis of underivatised oligosaccharides by Matrix-Assisted Laser Desorption Mass Spectrometry
TL;DR: Matrix assisted laser desorption mass spectrometry is shown to provide a rapid and sensitive technique for the analysis of underivatised oligosaccharides as mentioned in this paper, which is particularly useful for the extraction of oligosACcharide mixtures released from glycoproteins.
117