John Ramunas
Stanford University
23 Papers
435 Citations
John Ramunas is an academic researcher from Stanford University. The author has contributed to research in topics: Stem cell & Telomere. The author has an hindex of 13, co-authored 23 publications. Previous affiliations of John Ramunas include University of Waterloo.
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Papers
Support for the immortal strand hypothesis neural stem cells partition DNA asymmetrically in vitro
Phillip Karpowicz,Cindi M. Morshead,Angela Kam,Eric Jervis,John Ramunas,Vincent Cheng,Derek van der Kooy +6 more
TL;DR: It is demonstrated that NSCs are unique among precursor cells in the uneven partitioning of genetic material during cell divisions, and this results were further supported by real time imaging of SC clones, in which older and newly synthesized DNA templates were distributed asymmetrically after DNA synthesis.
197
High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal
Brad Dykstra,John Ramunas,David G. Kent,Lindsay McCaffrey,Erin Szumsky,Liam Kelly,Kristen Farn,April Blaylock,Connie J. Eaves,Eric Jervis +9 more
TL;DR: Characteristics associated with HSC activity included longer cell-cycle times and the absence of uropodia on a majority of cells within the clone during the final 12 h of culture, demonstrating the potential of this monitoring system to detect new features of proliferating HSCs that are predictive of self-renewal divisions.
138
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
John Ramunas,Eduard Yakubov,Jennifer J. Brady,Stéphane Y. Corbel,Colin Holbrook,Moritz Brandt,Jonathan Stein,Juan G. Santiago,John P. Cooke,Helen M. Blau +9 more
TL;DR: This rapid method of extending telomeres and increasing cell proliferative capacity without risk of insertional mutagenesis should have broad utility in disease modeling, drug screening, and regenerative medicine.
112
High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model.
Bryan Ronain Smith,Cristina Zavaleta,Jarrett Rosenberg,Ricky T. Tong,John Ramunas,Zhuang Liu,Hongjie Dai,Sanjiv S. Gambhir +7 more
TL;DR: The analysis revealed critical, quantitative insights into the dynamic, multifaceted mechanisms implicated in ligand-targeted SWNT accumulation in tumor using real-time observation and uncovered the complex spatiotemporal interplay between these competing uptake mechanisms.
53
Direct Evaluation of Myocardial Viability and Stem Cell Engraftment Demonstrates Salvage of the Injured Myocardium
Paul J Kim,Morteza Mahmoudi,Xiaohu Ge,Yuka Matsuura,Ildiko Toma,Scott A. Metzler,Nigel G. Kooreman,John Ramunas,Colin Holbrook,Michael V. McConnell,Helen M. Blau,Phillip Harnish,Eric Rulifson,Phillip C. Yang +13 more
TL;DR: The functional restoration seen in MiPSCs was characterized by increased myocardial viability and sustained engraftment without de novo cardiac differentiation, indicating salvage of the injured myocardium.