John R. G. Challis
University of Toronto
392 Papers
5.8K Citations
John R. G. Challis is an academic researcher from University of Toronto. The author has contributed to research in topics: Fetus & Placenta. The author has an hindex of 70, co-authored 392 publications. Previous affiliations of John R. G. Challis include McMaster University & Canadian Institutes of Health Research.
Chat about Author
Papers
Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development.
TL;DR: Results demonstrate that 11 beta-HSD gene expression in sheep is regulated in a tissue-specific and developmentally programmed manner.
Is there a role for probiotics in the prevention of preterm birth
Siwen Yang,Siwen Yang,Gregor Reid,Gregor Reid,John R. G. Challis,John R. G. Challis,Sung Ouk Kim,Sung Ouk Kim,Gregory B. Gloor,Alan D. Bocking,Alan D. Bocking +10 more
TL;DR: The ability of oral or vaginal lactobacilli probiotics to reduce BV occurrence and/or dampen inflammation is being considered as a means to prevent preterm birth.
Transcriptional Activity of Androgen Receptor Is Modulated by Two RNA Splicing Factors, PSF and p54nrb
TL;DR: It is demonstrated that PSF and p54nrb complex with AR and play a key role in modulating AR-mediated gene transcription, and the suppression of AR transcriptional activity is reversed by the inhibition of histone deacetylase activity.
Synergism between systemic corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin release in vivo varies as a function of gestational age in the ovine fetus.
TL;DR: It is concluded that in vivo the ovine fetal pituitary responds separately and synergistically to AVP and CRF on days 110-115 of gestation, but the relative role of AVP in stimulating ACTH release decreases with progressive gestational age.
Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep
TL;DR: Levels of POMC mRNA in the pars distalis are unchanged during long-term hypoxemia possibly because of negative feedback effects of elevated cortisol on the pituitary gland.