John R. G. Challis
University of Toronto
392 Papers
5.8K Citations
John R. G. Challis is an academic researcher from University of Toronto. The author has contributed to research in topics: Fetus & Placenta. The author has an hindex of 70, co-authored 392 publications. Previous affiliations of John R. G. Challis include McMaster University & Canadian Institutes of Health Research.
Chat about Author
Papers
Propranolol inhibits the maturational effect of adrenocorticotropin in the fetal sheep lung.
George A. Vilos,John R. G. Challis,George A. Pliagas,Stephen L. Lye,Fred Possmayer,Paul G.R. Harding +5 more
TL;DR: Propranolol inhibits the maturational effects of adrenocorticotropin on the fetal lung, which implies that the mechanism of pulmonary maturation is not solely dependent on endogenous cortisol and must be mediated, at least in part, through adrenergic responses.
4
•Journal Article
Accelerated prepartum maturation of the fetal sheep lung with physiological doses of andrenocorticotrophin.
TL;DR: It is concluded that the administration of low doses of ACTH markedly accelerate prepartum maturation of the intact ovine lung over 72 hours; the mechanism by which ACTH exerts this powerful maturation effect on the fetal lung remains to be elucidated.
4
Ontogeny of the insulin response to glucose in fetal and adult sheep.
TL;DR: In adult sheep glucose and insulin concentrations remained elevated at 120 min following the injection of glucose, whereas in the fetus the concentration of insulin had returned to preinjection values by 60 min, and the insulin/glucose ratio did not change in fetal lambs over the last one third of gestation and was not different from the adult sheep.
4