John R. G. Challis
University of Toronto
392 Papers
5.8K Citations
John R. G. Challis is an academic researcher from University of Toronto. The author has contributed to research in topics: Fetus & Placenta. The author has an hindex of 70, co-authored 392 publications. Previous affiliations of John R. G. Challis include McMaster University & Canadian Institutes of Health Research.
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Papers
Divergent changes in plasma ACTH and pituitary POMC mRNA after cortisol administration to late-gestation ovine fetus
T. M. Jeffray,T. M. Jeffray,T. M. Jeffray,Stephen G. Matthews,Geoffrey L. Hammond,Geoffrey L. Hammond,John R. G. Challis,John R. G. Challis,John R. G. Challis +8 more
TL;DR: In this paper, the plasma concentrations of cortisol and adrenocorticotropic hormone (ACTH) rise in the late-gestation sheep fetus at approximately the same time as there is an increase in the plasma levels of cortic...
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Effect of Labor on Glucocorticoid Receptor (GRTotal, GRα, and GRβ) Proteins in Ovine Intrauterine Tissues
Shalini Gupta,Shalini Gupta,S. Gyomorey,S. Gyomorey,Stephen J. Lye,Stephen J. Lye,William Gibb,William Gibb,John R. G. Challis,John R. G. Challis +9 more
TL;DR: The temporal and tissue-specific pattern of GR expression within ovine intrauterine tissues during labor implicates GR in regulating cortisol action to induce enzymatic changes controlling labor in sheep.
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Antenatal Glucocorticoid Administration Increases Corticotrophin-Releasing Hormone in Maternal Plasma
TL;DR: It is concluded that maternal betamethasone administration increases maternal plasma CRH values between 24 and 31 completed weeks of gestation.
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Regulation of corticosteroids in the fetus: control of birth and influence on adult disease
TL;DR: The findings emphasize the need for cautious use of synthetic glucocorticoids in pregnant women, and suggest that their administration should be confined to appropriate groups of high-risk pregnancies.
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