John Paul Mitchell
Cardiff University
4 Papers
26 Citations
John Paul Mitchell is an academic researcher from Cardiff University. The author has contributed to research in topics: Downregulation and upregulation & Biology. The author has an hindex of 4, co-authored 4 publications.
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Papers
Systemic complement profiling in multiple sclerosis as a biomarker of disease state
Gillian Ingram,Svetlana Hakobyan,Claire Louise Hirst,Claire L. Harris,Samantha Loveless,John Paul Mitchell,Trevor Pickersgill,Neil Robertson,Bryan Paul Morgan +8 more
TL;DR: These data provide further evidence of alterations in both local and systemic expression and activation of complement in MS and suggest that complement profiling may be informative as a biomarker of MS disease, although further work is needed to determine its use in distinguishing MS from its differential.
A look at HIV journey: from dendritic cells to infection spread in CD4⁺ T cells.
TL;DR: It is becoming evident that a better characterization of the early events of HIV transmission and the involvement of dendritic cell subtypes in this process would contribute to strengthen efforts to improve the current therapeutic and prophylactic strategies.
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β -TrCP Dependency of HIV-1 Vpu-Induced Downregulation of CD4 and BST-2/Tetherin
TL;DR: This review will detail recent research aimed at elucidating the mechanism of Vpu-mediated CD4 and BST-2/tetherin downregulation and degradation as well as their subsequent consequences on viral pathogenesis.
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Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1
Stephan M. Caucheteux,John Paul Mitchell,Matthew Owen Ivory,Sachiko Hirosue,Svetlana Hakobyan,Garry Dolton,Kristin Ladell,Kelly L. Miners,David Price,David Price,June Kan-Mitchell,Andrew K. Sewell,Frank O. Nestle,Arnaud Moris,Richard O. S. Karoo,James Caradoc Birchall,Melody A. Swartz,Jeffrey A. Hubbel,Fabien Blanchet,Vincent Piguet +19 more
TL;DR: An intradermal vaccine using HIV-1 p24 Gag peptide-conjugated polypropylene sulfide nanoparticle formulation did not accelerate the maturation of blood- or skin-derived subsets of dendritic cells, despite efficient uptake in the absence of adjuvant, and nanoparticle-based intrader mal antigen delivery may provide a new option in the global effort to develop an effective vaccine against HIV- 1.
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