John Nicholas
Johns Hopkins University School of Medicine
40 Papers
208 Citations
John Nicholas is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Lytic cycle & Primary effusion lymphoma. The author has an hindex of 19, co-authored 37 publications. Previous affiliations of John Nicholas include Johns Hopkins University.
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Papers
A Single 13-Kilobase Divergent Locus in the Kaposi Sarcoma- Associated Herpesvirus (Human Herpesvirus 8) Genome Contains Nine Open Reading Frames That Are Homologous to or Related to Cellular Proteins
John Nicholas,Vivian Ruvolo,Jianchao Zong,Dolores M. Ciufo,Hong Guang Guo,Marvin S. Reitz,Gary S. Hayward +6 more
TL;DR: It is concluded that the DL-B locus of gammaherpesviruses displays considerably more variability that previously appreciated and that expression of many of these genes is likely to have important implications for HHV-8 biology and therapy.
181
Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate.
TL;DR: The majority (70 to 80%) of samples from the mid-East Coast region at least appear to be virtually identical, supporting the concept that they may all derive from the spread during the AIDS epidemic of a single recently transmitted infectious agent.
134
Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir.
TL;DR: Experiments presented here show that both ORF 21 and ORF 36 encode GCV kinase activities as demonstrated by GCV phosphorylation and GCV-mediated cell death.
104
Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines
Young Bong Choi,John Nicholas +1 more
TL;DR: The data show for the first time that the v-chemokines have direct effects on virus biology, independently of their postulated immune evasion functions, and suggest that in vivo the v the chemokines might play direct roles in Kaposi's sarcomagenesis via paracrine prosurvival signaling.
61
Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus.
TL;DR: It is shown that HHV-8-encoded viral interferon regulatory factor 1 (vIRF-1) promotes mitochondrial clearance by activating mitophagy to support virus replication and that vIRf-1 inducedMitophagy supports productive infection.