John Monaghan
University of Pittsburgh
11 Papers
1 Citations
John Monaghan is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Neurodegeneration & Stress granule. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of John Monaghan include LSU Health Sciences Center New Orleans.
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Papers
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Xinmei Wen,Wenzhi Tan,Thomas Westergard,Karthik Krishnamurthy,Shashirekha S. Markandaiah,Yingxiao Shi,Shaoyu Lin,Neil A. Shneider,John Monaghan,Udai Bhan Pandey,Piera Pasinelli,Justin K. Ichida,Davide Trotti +12 more
TL;DR: Interestingly, G4C2 transcript-mediated neurotoxicity synergizes with that of PR aggregates, suggesting convergence of mechanisms.
537
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
Lin Guo,Hong Joo Kim,Hejia Wang,John Monaghan,Fernande Freyermuth,Julie C. Sung,Kevin J. O'Donovan,Charlotte M. Fare,Zamia Diaz,Nikita Singh,Zi Chao Zhang,Zi Chao Zhang,Maura Coughlin,Elizabeth A. Sweeny,Morgan E. DeSantis,Meredith E. Jackrel,Christopher B. Rodell,Jason A. Burdick,Oliver D. King,Aaron D. Gitler,Clotilde Lagier-Tourenne,Udai Bhan Pandey,Yuh Min Chook,J. Paul Taylor,J. Paul Taylor,James Shorter +25 more
TL;DR: Karyopherin-β2 prevents RBPs with PY-NLSs accumulating in stress granules, restores nuclear RBP localization and function, and rescues degeneration caused by disease-linked FUS and hnRNPA2, establishing that NIRs therapeutically restore RBP homeostasis and mitigate neurodegeneration.
446
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
J. Gavin Daigle,Nicholas A. Lanson,Rebecca B. Smith,Ian Casci,Astha Maltare,John Monaghan,Charles D. Nichols,Dmitri Kryndushkin,Frank Shewmaker,Udai Bhan Pandey +9 more
TL;DR: It is demonstrated that the RNA-binding ability of FUS is essential for the neurodegenerative phenotype in vivo of mutant FUS (either through direct contact with RNA or through interactions with other RBPs).
Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy
Chiara Scaramuzzino,Ian Casci,Sara Parodi,Sara Parodi,Patricia M.-J. Lievens,Patricia M.-J. Lievens,María José Polanco,María José Polanco,Carmelo Milioto,Carmelo Milioto,Mathilde Chivet,John Monaghan,Ashutosh Mishra,Nisha M. Badders,Tanya Aggarwal,Christopher Grunseich,Fabio Sambataro,Manuela Basso,Frank O. Fackelmayer,J. Paul Taylor,Udai Bhan Pandey,Maria Pennuto,Maria Pennuto +22 more
TL;DR: It is shown here that protein arginine methyltransferase 6 (PRMT6) is a specific co-activator of normal and mutant AR and that the interaction of PRMT6 with AR is significantly enhanced in the AR mutant, which leads to neurodegeneration in cell and fly models of SBMA.
97
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
Chiara Scaramuzzino,John Monaghan,Carmelo Milioto,Nicholas A. Lanson,Astha Maltare,Tanya Aggarwal,Ian Casci,Frank O. Fackelmayer,Maria Pennuto,Udai Bhan Pandey +9 more
TL;DR: It is found that wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation in cultured cells, which support a role for arkinine methylation in the pathogenesis of FUS-related ALS.