John M. Lu
Laboratory of Molecular Biology
6 Papers
47 Citations
John M. Lu is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Chemistry & Capsid. The author has an hindex of 2, co-authored 2 publications.
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Papers
Structures and distributions of SARS-CoV-2 spike proteins on intact virions.
Zunlong Ke,Joaquín Otón,Kun Qu,Mirko Cortese,Vojtech Zila,Lesley McKeane,Takanori Nakane,Jasenko Zivanov,Christopher J. Neufeldt,Berati Cerikan,John M. Lu,Julia Peukes,Xiaoli Xiong,Hans-Georg Kräusslich,Sjors H.W. Scheres,Ralf Bartenschlager,Ralf Bartenschlager,John A. G. Briggs +17 more
TL;DR: Cryo-electron microscopy and tomography is applied to image intact SARS-CoV-2 virions, determining the high-resolution structure, conformational flexibility and distribution of S trimers in situ on the virion surface and providing a basis from which to understand interactions between S and neutralizing antibodies during infection or vaccination.
Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions
Zunlong Ke,Joaquín Otón,Kun Qu,Mirko Cortese,Vojtech Zila,Lesley McKeane,Takanori Nakane,Jasenko Zivanov,Christopher J. Neufeldt,John M. Lu,Julia Peukes,Xiaoli Xiong,Hans-Georg Kräusslich,Sjors H.W. Scheres,Ralf Bartenschlager,John A. G. Briggs +15 more
TL;DR: Cryo-electron microscopy and tomography is applied to image intact SARS-CoV-2 virions, determining the high-resolution structure, conformational flexibility and distributions of S trimers in situ on the virion surface to provide a basis for understanding the conformations of S present on thevirion, and for studying their interactions with neutralizing antibodies.
Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model.
Shamik Mascharak,Michelle Griffin,Heather E. Talbott,Jason L. Guo,J. Parker,A. Morgan,Caleb Valencia,Max Kuhnert,Dayan J. Li,Norah E. Liang,Rachel M. Kratofil,Joseph Daccache,Ikjot Sidhu,Michael F. Davitt,Nicholas Guardino,John M. Lu,Darren B. Abbas,Nestor M D Deleon,Christopher V. Lavin,Sandeep Adem,Anum Khan,Kellen Chen,Dominic Henn,Amanda Spielman,Asha C. Cotterell,Deena Akras,Mauricio A. Downer,Ruth Tevlin,H. P. Lorenz,Geoffrey C. Gurtner,Michael Januszyk,S.Chakravarthy Naik,Derrick C. Wan,Michael T. Longaker +33 more
6
Histological signatures map anti-fibrotic factors in mouse and human lungs.
Jason L. Guo,Michelle Griffin,Jung-Ki Yoon,David M Lopez,Yili Zhu,John M. Lu,Georgios Mikos,J. Parker,Shamik Mascharak,Camille Brenac,Nicholas Guardino,Darren B. Abbas,Dayan J. Li,Caleb Valencia,Norah E. Liang,Michael Januszyk,Howard Y. Chang,Derrick C. Wan,Tushar J. Desai,Michael T. Longaker +19 more
4
Growth arrest specific-6 and angiotoxin receptor-like signaling drive oral regenerative wound repair.
Michelle F Griffin,Jessica Cook,A. Morgan,Dario Boffelli,Mauricio A. Downer,Amanda Spielman,Nicholas Guardino,Jason L. Guo,J. Parker,Michael Januszyk,Caleb Valencia,Max Kuhnert,John M. Lu,Rachel Zwick,Derrick C. Wan,Ophir D. Klein,M. Longaker +16 more