John Lehmann
Novartis
22 Papers
506 Citations
John Lehmann is an academic researcher from Novartis. The author has contributed to research in topics: NMDA receptor & Dopamine. The author has an hindex of 15, co-authored 22 publications. Previous affiliations of John Lehmann include G. D. Searle & Company.
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Papers
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
TL;DR: Two potent, selective and competitive NMDA antagonists, cis-4-(phosphonomethyl)-2-piperidine-carboxylic acid (CGS 19755) and CPP, were characterized in the gerbil ischemia model with respect to dose-response and time course effects and were effective in reducing ischemic brain damage and associated hypermotility.
254
•Journal Article
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
John Lehmann,J Schneider,S E McPherson,Deborah E. Murphy,P S Bernard,C Tsai,Debra A. Bennett,G Pastor,D J Steel,C Boehm +9 more
TL;DR: In conclusion, based upon the competitive antagonism by CPP of NMDA-evoked [3H] ACh release in vitro and the antagonism ofNMDA-induced convulsions in vivo, the data presented are consistent with competitive antagonisms of NMda-type receptors.
252
•Journal Article
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
John Lehmann,Hutchison Alan J,S E McPherson,C Mondadori,Markus Schmutz,C M Sinton,C Tsai,Deborah E. Murphy,D J Steel,Michael Williams +9 more
TL;DR: CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evokes, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum, suggesting a competitive interaction with NMDA-type receptors.
231
•Journal Article
Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors
TL;DR: CPP binding was stereoselective for the isomers of glutamate, 2-amino-5-phosphonopentanoic acid, homocysteic acid and N-methyl-aspartate, and the most potent compounds tested were L-glutamate and CPP, which were equiactive in displacing [3H]CPP.
211
Interactions of phencyclidine receptor agonist MK-801 with dopaminergic system: regional studies in the rat.
TL;DR: Results indicated that MK‐801 may act at the cell body as well as the nerve terminal level to increase DA metabolism and that ongoing dopaminergic neuronal activity is a prerequisite for full drug action.
117