John Lawrence Andreassi
DuPont
10 Papers
64 Citations
John Lawrence Andreassi is an academic researcher from DuPont. The author has contributed to research in topics: Mevalonate kinase & Oomycete. The author has an hindex of 5, co-authored 10 publications.
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Papers
Mesoionic insecticides: a novel class of insecticides that modulate nicotinic acetylcholine receptors
Caleb William Holyoke,Daniel Cordova,Wenming Zhang,James D. Barry,Robert M. Leighty,Robert F. Dietrich,James J. Rauh,Thomas F. Pahutski,George Philip Lahm,My-Hanh Thi Tong,Eric A. Benner,John Lawrence Andreassi,Rejane M. Smith,Daniel R. Vincent,Laurie A. Christianson,Luís A. F. Teixeira,Vineet Singh,Kenneth A. Hughes +17 more
TL;DR: Triflumezopyrim insect control will provide a powerful tool for control of hopper species in rice throughout Asia and Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests.
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Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate
John Lawrence Andreassi,Patrick W. Bilder,Matthew W. Vetting,Steven L. Roderick,Thomas S. Leyh +4 more
TL;DR: Structural comparison of SpMK with other members of the GHMP kinase family reveals that DPM functions as a partial bisubstrate analog (mevalonate linked to the pyrophosphoryl moiety of ATP) in that it elicits a ternary‐complexlike form of the enzyme, except for localized disordering in a region that would otherwise interact with the missing portion of the nucleotide.
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Structure of the Ternary Complex of Phosphomevalonate Kinase: The Enzyme and Its Family
John Lawrence Andreassi,Matthew W. Vetting,Patrick W. Bilder,Steven L. Roderick,Thomas S. Leyh +4 more
TL;DR: Analysis of all available GHMP kinase ternary complex structures reveals that while their C(alpha)-scaffolds are highly conserved, their substrates bind in one of two conformations, which appear to be either reactive or nonreactive.
The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action
Robert James Pasteris,Mary Ann Hanagan,John J. Bisaha,Bruce Lawrence Finkelstein,Lisa E. Hoffman,Vann Gregory,Christopher P. Shepherd,John Lawrence Andreassi,James A. Sweigard,Boris A. Klyashchitsky,Yewande T. Henry,Richard A. Berger +11 more
- 01 Jan 2015
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Patent
Dihydroorotate dehydrogenase inhibitor compositions effective as herbicides
Steven Gutteridge,Il-Ho Kang,John Lawrence Andreassi +2 more
- 30 Oct 2016
TL;DR: In this paper, the authors proposed a method for the production of herbicidal compounds and compositions comprising the same which inhibit dihydroorotate dehydrogenase (DOR) enzymes.
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