John Langdon
University of Cambridge
47 Papers
926 Citations
John Langdon is an academic researcher from University of Cambridge. The author has contributed to research in topics: Epidermoid carcinoma & Mouth neoplasm. The author has an hindex of 24, co-authored 47 publications.
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Papers
•Journal Article
A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization.
Maxine Partridge,Stelios Pateromichelakis,E. Phillips,G. Emilion,Roger P. A’Hern,John Langdon +5 more
TL;DR: It is suggested that the process of field cancerization is more widespread than previously recognized and recommended complete excision of all suspicious areas that show AI at two or more key loci, regardless of the degree of dysplasia.
183
•Journal Article
Detection of Minimal Residual Cancer to Investigate Why Oral Tumors Recur Despite Seemingly Adequate Treatment
M. Partridge,Shu-Rui Li,Stelios Pateromichelakis,Rebecca Francis,E. Phillips,Xiaohong Huang,Fis Tesfa-Selase,John Langdon +7 more
TL;DR: It is revealed that molecular and immunocytochemical detection of minimal residual cancer and field cancerization can help identify patients who may develop locoregional or distant recurrence and justify further studies to evaluate the contribution of these remaining malignant cells to treatment failure.
168
Expression of the tumour suppressor gene p53 in oral cancer.
John Langdon,M. Partridge +1 more
TL;DR: In this article, the product of the tumour suppressor gene p53 was detected in 12/15 cases of oral squamous cell carcinoma (SCC) and in two cases of leukoplakia.
94
Expression of epidermal growth factor receptor on oral squamous cell carcinoma
TL;DR: The expression of the receptor for epidermal growth factor (EGF) in normal oral mucosa, papillomas and squamous cell carcinoma (SCC) has been determined by immunohistology and autophophorylation studies and there was no significant correlation between the level of EGFR expression and tumour behaviour.
88
•Journal Article
Detection of Rare Disseminated Tumor Cells Identifies Head and Neck Cancer Patients at Risk of Treatment Failure
M. Partridge,Ruud H. Brakenhoff,E. Phillips,Kulsan Ali,Rebecca Francis,Richard Hooper,K.M. Lavery,A.E. Brown,John Langdon +8 more
TL;DR: It is suggested that detection of DTCs pre- or intraoperatively indicates a high risk of local and distant recurrence and reduced survival in head and neck cancer.
87