John L. Ryan
Pfizer
9 Papers
51 Citations
John L. Ryan is an academic researcher from Pfizer. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of John L. Ryan include University of California, Davis & Yale University.
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Papers
Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production
John P. Leonard,Matthew L. Sherman,Gerald L. Fisher,Lynn J. Buchanan,Glenn R. Larsen,Michael B. Atkins,Jeffrey A. Sosman,Janice P. Dutcher,Nicholas J. Vogelzang,John L. Ryan +9 more
TL;DR: It is determined that a single injection of rhIL-12 2 weeks before consecutive dosing included in the Phase 1 study, but not in the schedule of administration in thephase 2 study, has a profound abrogating effect on IL-12–induced interferon-γ (IFN-γ) production and toxicity.
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The Antiparasitic Moxidectin: Safety, Tolerability, and Pharmacokinetics in Humans
Monette M. Cotreau,Sarah Warren,John L. Ryan,Lawrence Fleckenstein,Sreenivasa R. Vanapalli,Kenneth Brown,David Rock,Chieh-Yu Chen,Ullrich S. Schwertschlag +8 more
TL;DR: The results from this study indicate that MOX is safe and well tolerated in humans between the doses of 3 mg and 36 mg.
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A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides.
Madeleine Duvic,Matthew L. Sherman,Gary S. Wood,Timothy M. Kuzel,Elise A. Olsen,Francine M. Foss,Robert Laliberte,John L. Ryan,Kristilyn Zonno,Alain H. Rook +9 more
TL;DR: In this article, the safety and efficacy of subcutaneous recombinant human IL-12 (rhIL-12) in early mycosis fungoides (MF; stage IA-IIA) in a multi-center, open label clinical trial were evaluated.
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Bacterial LPS and CpG DNA differentially induce gene expression profiles in mouse macrophages.
Jian Jun Gao,Veronica Diesl,Tatiana Wittmann,David C. Morrison,John L. Ryan,Stefanie N. Vogel,Maximillian T. Follettie +6 more
TL;DR: Macrophage gene expression profiles studied indicate that the CpG DNA signaling pathway through TLR9 activates only a subset of genes induced by the LPS TLR4 signaling pathway.
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Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: arthritis decreases while carditis persists
Juan Anguita,Stephen W. Barthold,Swapna Samanta,Swapna Samanta,Swapna Samanta,John L. Ryan,John L. Ryan,John L. Ryan,Erol Fikrig,Erol Fikrig,Erol Fikrig +10 more
TL;DR: IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice, suggesting a predominant effect of IL-11 on the innate immune response.
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