John Kirkpatrick
Leibniz University of Hanover
15 Papers
18 Citations
John Kirkpatrick is an academic researcher from Leibniz University of Hanover. The author has contributed to research in topics: RNA & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 6, co-authored 15 publications. Previous affiliations of John Kirkpatrick include Leibniz Institute for Neurobiology.
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Papers
Molecular mechanism of SHP2 activation by PD-1 stimulation
Michelangelo Marasco,Anna Berteotti,J. Weyershaeuser,Niko Thorausch,Justyna Sikorska,Joern Krausze,H. J. Brandt,John Kirkpatrick,Pablo Rios,Wolfgang W. A. Schamel,Maja Köhn,Teresa Carlomagno +11 more
TL;DR: It is demonstrated that full activation is obtained only upon phosphorylation of both ITIM and ITSM: ITSM binds C-SH2 with strong affinity, recruiting SHP2 to PD-1, while ITIM binds N- SH2, displacing it from the catalytic pocket and activating ShP2.
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Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein.
Bernd Simon,John Kirkpatrick,Stephanie Eckhardt,Michael Reuter,Elsa A. Rocha,Miguel A. Andrade-Navarro,Peter Sehr,Ramesh S. Pillai,Teresa Carlomagno +8 more
TL;DR: The solution structure of the PAZ domain from the mouse Piwi protein, MIWI, in complex with an 8-mer piRNA mimic is presented, similar to that of Ago-PAZ, but subtle differences illustrate how the PAz domain has evolved to accommodate distinct 3' ends from a variety of RNA substrates.
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Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications
Nadide Altincekic,Sophie Marianne Korn,Nusrat S. Qureshi,Marie Dujardin,Martí Ninot-Pedrosa,Rupert Abele,Marie Jose Abi Saad,Caterina Alfano,Fabio C. L. Almeida,Islam Alshamleh,Gisele Cardoso Amorim,Thomas K. Anderson,Cristiane D. Anobom,Chelsea Anorma,Jasleen Kaur Bains,Adriaan Bax,Martin Blackledge,Julius Blechar,Anja Böckmann,Louis Brigandat,Anna Bula,Matthias Bütikofer,Aldo R. Camacho-Zarco,Teresa Carlomagno,Ícaro Putinhon Caruso,Ícaro Putinhon Caruso,Betül Ceylan,Apirat Chaikuad,Apirat Chaikuad,Feixia Chu,Laura Cole,Marquise G. Crosby,Vanessa de Jesus,Karthikeyan Dhamotharan,Isabella C. Felli,Jan Ferner,Yanick Fleischmann,Marie-Laure Fogeron,Nikolaos K. Fourkiotis,Christin Fuks,Boris Fürtig,Angelo Gallo,Santosh Lakshmi Gande,Juan Atilio Gerez,Dhiman Ghosh,Francisco Gomes-Neto,Francisco Gomes-Neto,Oksana Gorbatyuk,Serafima Guseva,Carolin Hacker,Sabine Häfner,Bing Hao,Bruno Hargittay,Katherine A. Henzler-Wildman,Jeffrey C. Hoch,Katharina F. Hohmann,Marie T. Hutchison,Kristaps Jaudzems,Katarina Jović,Janina Kaderli,Gints Kalniņš,Iveta Kaņepe,Robert N. Kirchdoerfer,John Kirkpatrick,Stefan Knapp,Stefan Knapp,Robin Krishnathas,Felicitas Kutz,Susanne zur Lage,Roderick Lambertz,Andras Lang,Douglas V. Laurents,Lauriane Lecoq,Verena Linhard,Frank Löhr,Anas Malki,Luiza Mamigonian Bessa,Rachel W. Martin,Tobias Matzel,Damien Maurin,Seth W. McNutt,Nathane C. Mebus-Antunes,Beat H. Meier,Nathalie Meiser,Miguel Mompeán,Elisa Monaca,Roland Montserret,Laura Mariño Perez,Celine Moser,Claudia Muhle-Goll,Thais Cristtina Neves-Martins,Xiamonin Ni,Xiamonin Ni,Brenna Norton-Baker,Roberta Pierattelli,Letizia Pontoriero,Yulia Pustovalova,Oliver Ohlenschläger,Julien Orts,Andrea T. Da Poian,Dennis J. Pyper,Christian Richter,Roland Riek,Chad M. Rienstra,Angus J. Robertson,Anderson S. Pinheiro,Raffaele Sabbatella,Nicola Salvi,Krishna Saxena,Linda Schulte,Marco Schiavina,Harald Schwalbe,Mara Silber,Marcius S. Almeida,Marc A. Sprague-Piercy,Georgios A. Spyroulias,Sridhar Sreeramulu,Jan-Niklas Tants,Kaspars Tārs,Felix Torres,Sabrina Töws,Miguel A. Treviño,Sven Trucks,Aikaterini C. Tsika,Krisztina Varga,Ying Wang,Marco E. Weber,Julia E. Weigand,Christoph Wiedemann,Julia Wirmer-Bartoschek,Maria Alexandra Wirtz Martin,Johannes Zehnder,Martin Hengesbach,Andreas Schlundt +133 more
TL;DR: In this paper, the authors present an extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the COVID19-NMR consortium's collective efforts.
Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network.
TL;DR: In this paper, the authors show that pY-recognition leads to enhanced dynamics of the N-SH2 EF and BG loops via an allosteric communication network, which destabilizes the NSH2-PTP interaction surface and simultaneously generates a fully accessible binding pocket for the C-terminal half of the phosphopeptide.
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Histone chaperone exploits intrinsic disorder to switch acetylation specificity.
Nataliya Danilenko,Lukas Lercher,John Kirkpatrick,Frank Gabel,Luca Codutti,Teresa Carlomagno +5 more
TL;DR: A structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4 is established, finding that Vps 75 promotes K9-acetylation by engaging the H3 N-Terminal tail in fuzzy electrostatic interactions with its disordered C-terminal domain.