John J. Salisbury
Pfizer
7 Papers
12 Citations
John J. Salisbury is an academic researcher from Pfizer. The author has contributed to research in topics: Gas chromatography & Flame ionization detector. The author has an hindex of 4, co-authored 7 publications.
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Papers
Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin
Paul Bowles,Steven J. Brenek,Stephane Caron,Nga M. Do,Michele T. Drexler,Shengquan Duan,Pascal Dube,Eric C. Hansen,Brian P. Jones,Kris N. Jones,Tomislav A. Ljubicic,Teresa W. Makowski,Jason Mustakis,Jade D. Nelson,Mark Olivier,Zhihui Peng,Hahdi H. Perfect,David Place,John A. Ragan,John J. Salisbury,Corey L. Stanchina,Brian C. Vanderplas,Mark E. Webster,R. Matt Weekly +23 more
TL;DR: A practical synthesis of SGLT2 inhibitor candidate ertugliflozin has been developed for potential commercial application and high chemical purity of the API is assured through isolation of the crystalline penultimate intermediate, tetraacetate 39.
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Fused-Core Particles: A Practical Alternative to Sub-2 Micron Particles
TL;DR: The goal for this research was to test these columns for efficiency and robustness utilizing a mixture of Torcetrapib and its relative impurities, and results indicate that excellent theoretical plates were achievable for run times less than 5 min.
Application of quantitative 19F and 1H NMR for reaction monitoring and in situ yield determinations for an early stage pharmaceutical candidate.
TL;DR: The application of (19)F and (1)H qNMR for reaction monitoring and in situ potency determinations will be discussed for an early stage pharmaceutical candidate with several analytical challenges.
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Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten
Janice E. Sieser,Mark T. Maloney,Esmort Chisowa,Steven J. Brenek,Sebastien Monfette,John J. Salisbury,Nga M. Do,Robert A. Singer +7 more
TL;DR: The original process in early development used an Ir-catalyzed borylation reaction to enable rapid derivatization of nicotine with the desired regiocontrol and was very efficient, but required chromatography to meet purity targets.
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Validation of an enantioselective analysis for (l)-pidolic acid by chiral gas chromatography with derivatization
TL;DR: A sensitive and rapid analytical method has been validated for the enantiomeric purity determination of l-pidolic acid, a biological lactam and metabolite of glutamic acid commonly found in urine, skin, bones, brain and is available commercially as a food supplement.
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