John J. Hemperly
Rockefeller University
12 Papers
478 Citations
John J. Hemperly is an academic researcher from Rockefeller University. The author has contributed to research in topics: Peptide sequence & Alternative splicing. The author has an hindex of 10, co-authored 12 publications.
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Papers
Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions
TL;DR: At least a portion of the N-CAM binding site was found to be located in the amino-terminal region of the peptide chain, raising the possibility that valence may play a key role in N-cAM binding.
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cDNA clones of the neural cell adhesion molecule (N-CAM) lacking a membrane-spanning region consistent with evidence for membrane attachment via a phosphatidylinositol intermediate
TL;DR: It is shown here that the ssd chain of chicken N-CAM can be released from brain vesicles by treatment with phospholipase C, suggesting that it too may have a phosphatidylinositol anchor.
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Circular permutation of amino acid sequences among legume lectins
TL;DR: Lectins from leguminous plants are closely related to each other and are related to the jack bean lectin Concanavalin A by an unusual circular permutation of amino acid sequences.
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Structure of the gene for the liver cell adhesion molecule, L-CAM.
TL;DR: This article used restriction digests of chicken genomic DNA with cDNA and genomic probes to isolate genomic clones covering the entire L-CAM coding sequence and found that there is no evidence for alternative splicing of exons in this gene in contrast to genes for other cell-cell or cell-substrate adhesion molecules.
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Monovalent derivatives of concanavalin A.
TL;DR: Experiments indicated that the resultant preparations consisted mainly of monovalent dimers which showed subunit exchange to yield about 15% divalent dimers after 12 hr at physiological pH, which should allow a refined analysis of the effects of lectin valence at the cell surface.
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