John Hussey
University of Glasgow
9 Papers
1 Citations
John Hussey is an academic researcher from University of Glasgow. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 1, co-authored 1 publications.
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Papers
Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis
Christina Elliott,Maren Lindner,Ariel Arthur,Kathryn M. Brennan,Sven Jarius,John Hussey,Andrew T. Chan,Anke Stroet,Tomas Olsson,Hugh J. Willison,Hugh J. Willison,Susan C. Barnett,Edgar Meinl,Christopher Linington +13 more
TL;DR: This study identifies axopathic and/or demyelinating autoantibody responses in a subset of patients with multiple sclerosis, which underlines the mechanistic heterogeneity of multiple sclerosis and provides a rational explanation why some patients benefit from antibody depleting treatments.
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Calmodulin Mutations in Human Disease
TL;DR: A review of the research that has been done to identify calmodulinopathic CaM mutations and evaluate the mechanisms underlying their role in disease can be found in this paper , where the authors identify several proteins modulated by CaM that are likely to underlie the pathogenesis of these calmodulopathies.
22
CACNA1C-Related Channelopathies.
TL;DR: In this paper , the impact of genetic mutations on CaV1.2 function and the resultant physiological consequences is reviewed, and the number and variety of disease-associated mutations identified in CACNA1C have grown tremendously, expanding the range of phenotypes observed in affected patients.
14
Elucidating the role Cav1.2 dysfunction in the pathogenesis of timothy syndrome using iPSC-derived neurons.
Kevin Herold,Moradeke A. Bamgboye,Deborah DiSilvestre,John Hussey,Josiah O. Owoyemi,Ivy E. Dick +5 more
TL;DR: In this article , the L-type Ca2+ channel (LTCC) is critical for normal function of the heart and brain, and mutations in this channel have been linked to severe cardiac and neurodevelopmental disorders.
2
Evaluating the impact of Cav1.2 mutations on neuronal function
Kevin Herold,Moradeke A. Bamgboye,Daiana Cardoso Oliveira Vieira,Deborah DiSilvestre,John Hussey,Josiah O. Owoyemi,Andrea L. Meredith,Ivy E. Dick +7 more
TL;DR: In this article , a single point mutation in the CaV1.2 L-type Ca2+ channel (LTCC) has been shown to disrupt channel regulation, leading to an increased number of known mutations in the channel.