John Hensley
University of Michigan
9 Papers
15 Citations
John Hensley is an academic researcher from University of Michigan. The author has contributed to research in topics: Chromatin & Epigenomics. The author has an hindex of 5, co-authored 9 publications.
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Papers
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
Arushi Varshney,Laura J. Scott,Ryan P. Welch,Michael R. Erdos,Peter S. Chines,Narisu Narisu,Ricardo D’Oliveira Albanus,Peter Orchard,Brooke N. Wolford,Romy Kursawe,Swarooparani Vadlamudi,Maren E Cannon,John P. Didion,John Hensley,Anthony Kirilusha,Lori L. Bonnycastle,D. Leland Taylor,D. Leland Taylor,Richard M. Watanabe,Karen L. Mohlke,Michael Boehnke,Francis S. Collins,Stephen C. J. Parker,Michael L. Stitzel +23 more
TL;DR: The largest integrated analysis to date of high-resolution, high-throughput human islet molecular profiling data is presented to characterize the genome, epigenome, and transcriptome and find that T2D genetic variants are enriched in regions of the genome where transcription Regulatory Factor X (RFX) is predicted to bind in an islet-specific manner.
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Quantification, Dynamic Visualization, and Validation of Bias in ATAC-Seq Data with ataqv.
TL;DR: Ataqv is presented, a computational toolkit for efficiently measuring, visualizing, and comparing quality control (QC) results across samples and experiments and used to analyze 2,009 public ATAC-seq datasets.
76
Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice.
Peter Orchard,James S. White,Peedikayil E. Thomas,Anna Mychalowych,Anya Kiseleva,John Hensley,Benjamin L. Allen,Stephen C. J. Parker,Catherine E. Keegan +8 more
TL;DR: Substantial transcriptome changes in the Sd mouse are demonstrated, indicating that the effect of the ERV insertion on PTF1a expression may be mediated by increased chromatin accessibility at a conserved Ptf1a enhancer.
Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s short tail mice
Peter Orchard,James S. White,Peedikayil E. Thomas,Anna Mychalowych,Anya Kiseleva,John Hensley,Benjamin L. Allen,Stephen C. J. Parker,Catherine E. Keegan +8 more
TL;DR: Substantial transcriptome changes in the Sd mouse are demonstrated, and the effect of the ERV insertion on PTF1a expression may be mediated by increased chromatin accessibility at a conserved Ptf1a enhancer, which is conserved in mice and humans.
5
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
Laura J. Scott,Michael R. Erdos,Jeroen R. Huyghe,Ryan P. Welch,Andrew T. Beck,Brooke N. Wolford,Peter S. Chines,John P. Didion,Narisu Narisu,Heather M. Stringham,D. Leland Taylor,D. Leland Taylor,Anne U. Jackson,Swarooparani Vadlamudi,Lori L. Bonnycastle,Leena Kinnunen,Jouko Saramies,Jouko Sundvall,Ricardo D’Oliveira Albanus,Anna Kiseleva,John Hensley,Gregory E. Crawford,Hui Jiang,Xiaoquan Wen,Richard M. Watanabe,Timo A. Lakka,Karen L. Mohlke,Markku Laakso,Jaakko Tuomilehto,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Michael Boehnke,Francis S. Collins,Stephen C. J. Parker +34 more
TL;DR: In this article, the authors analyse skeletal muscle biopsies from 271 well-phenotyped Finnish participants with glucose tolerance ranging from normal to newly diagnosed Type 2 diabetes (T2D) to understand how T2D status, metabolic traits and genetic variation influence gene expression.