John G.F. Cleland
National Institutes of Health
1299 Papers
11.2K Citations
John G.F. Cleland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 137, co-authored 1172 publications. Previous affiliations of John G.F. Cleland include Northwestern University & Imperial College London.
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Papers
Systematic Reporting Bias in Meta-analyses of Trials of Aspirin for the Primary Prevention of Cardiovascular Disease
TL;DR: The authors did not include the Pulmonary Embolism revention Trial that enrolled 17,444 patients without overt ardiovascular disease undergoing surgery for hip fractures r elective arthroplasty, and the reporting bias in trials of aspirin is of concern.
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Early and late renal function changes with spironolactone in patients at risk of developing heart failure: findings from the HOMAGE trial
João Pereira,John G.F. Cleland,Nicolas Girerd,Pierpaolo Pellicori,Mark R. Hazebroek,Job Verdonschot,Timothy Collier,Johannes Petutschnigg,Andrew E. Clark,Jan A. Staessen,Stephane Heymans,Faiez Zannad,Patrick Rossignol +12 more
TL;DR: In the HOMAGE trial enrolling patients with risk factors for developing heart failure, spironolactone reduced markers of collagen synthesis, blood pressure, natriuretic peptides, and improved cardiac structure and function, while decreasing eGFR by ~ 5 ml/ min/1.73 m2.
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Clinical trials update from the European Society of Cardiology Heart Failure meeting: COMET, COMPANION, Tezosentan and SHAPE.
TL;DR: The results of a study on tezosentan suggest that lower doses of this endothelin antagonist may be clinically more effective with fewer adverse effects compared with higher doses.
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Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study.
Jana Anderson,Frederick K. Ho,Claire L. Niedzwiedz,Srinivasa Vittal Katikireddi,Carlos Celis-Morales,Stamatina Iliodromiti,Paul Welsh,Pierpaolo Pellicori,Evangelia Demou,Claire E. Hastie,Donald M. Lyall,Stuart R. Gray,John F. Forbes,Jason M.R. Gill,Daniel F. Mackay,Colin Berry,John G.F. Cleland,Naveed Sattar,Jill P. Pell +18 more
TL;DR: In this article, the authors investigated possible association between venous thromboembolism (VTE) and COVID-19 severity, independent of other risk factors such as socio-demographic, lifestyle and comorbid covariates.
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Diabetes, aliskiren, and heart failure: let's bring ASTRONAUT down to earth.
TL;DR: This editorial refers to ‘Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial’, by A.P. Maggioni et al.
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