John F. Keaney
University of Massachusetts Medical School
292 Papers
3.1K Citations
John F. Keaney is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Medicine & Endothelium. The author has an hindex of 99, co-authored 273 publications. Previous affiliations of John F. Keaney include Boston University & Boston Medical Center.
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Papers
Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.
TL;DR: It is concluded that probucol, a lipid-soluble antioxidant, preserves EDRF action in cholesterol-fed rabbits in association with limiting vascular oxidative stress and superoxide generation.
Nitric oxide released from activated platelets inhibits platelet recruitment.
Jane E. Freedman,Joseph Loscalzo,Marc R. Barnard,Caroline S. Alpert,John F. Keaney,Alan D. Michelson +5 more
TL;DR: In this paper, the role of platelet-derived NO in platelet recruitment was investigated and it was shown that platelet derived NO may regulate platelet activation and recruitment to a growing thrombus.
Atherosclerotic Biomarkers and Aortic Atherosclerosis by Cardiovascular Magnetic Resonance Imaging in the Framingham Heart Study
Susie N. Hong,Philimon Gona,Philimon Gona,João D. Fontes,Noriko Oyama,Raymond H. Chan,Satish Kenchaiah,Connie W. Tsao,Connie W. Tsao,Susan B. Yeon,Renate B. Schnabel,John F. Keaney,Christopher J. O'Donnell,Christopher J. O'Donnell,Emelia J. Benjamin,Warren J. Manning +15 more
TL;DR: The results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
Maja Barbalić,Josée Dupuis,Abbas Dehghan,Joshua C. Bis,Ron C. Hoogeveen,Renate B. Schnabel,Vijay Nambi,Monique Bretler,Nicholas L. Smith,Annette Peters,Chen Lu,Russell P. Tracy,Nena Aleksic,Jan Heeriga,John F. Keaney,Kenneth Rice,Gregory Y.H. Lip,Ramachandran S. Vasan,Nicole L. Glazer,Martin G. Larson,André G. Uitterlinden,Jennifer F. Yamamoto,Peter Durda,Talin Haritunians,Bruce M. Psaty,Eric Boerwinkle,Albert Hofman,Wolfgang Koenig,Nancy S. Jenny,Jacqueline C.M. Witteman,Christie M. Ballantyne,Emelia J. Benjamin +31 more
TL;DR: The absence of an association between ABO blood group and platelet-bound P-selectin levels in an independent subsample from the ARIC study, suggests that the ABOBlood group may influence cleavage of the P- selectin protein from the cell surface or clearance from the circulation, rather than its production and cellular presentation.
B-1 B Cell-Derived Natural Antibodies against N-Acetyl-d-Glucosamine Suppress Autoimmune Diabetes Pathogenesis.
J. New,Brian Dizon,R. Glenn King,Neil S. Greenspan,John F. Keaney +4 more
TL;DR: It is shown that neonatal immunization with group A Streptococcus suppresses T1D development in NOD mice by promoting clonal expansion of N-acetyl-d-glucosamine-specific B-1 B cells that recognize pancreatic β cell-derived Ags bearing GlcNAc-containing posttranslational modifications, thereby suppressing diabetogenic T cell activation.